CRYAB
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Official Full Name
crystallin, alpha B -
Overview
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the;major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens;central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout;life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma;families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided;into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting;peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B,;for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat;shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature;proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates.;Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40;subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha;crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene;products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed;widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a;missense mutation cosegregated in a family with a desmin-related myopathy. -
Synonyms
CRYAB;crystallin, alpha B;CRYA2;alpha-crystallin B chain;HSPB5;heat shock protein beta-5;rosenthal fiber component;heat-shock 20 kD like-protein;renal carcinoma antigen NY-REN-27;CTPP2
Recombinant Proteins
- Rhesus macaque
- Rat
- Human
- Mouse
- Cynomolgus
- Chicken
- Bovine
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- DDK
- Myc
- Flag
- Avi
- Fc
- SUMO
Involved Pathway
CRYAB involved in several pathways and played different roles in them. We selected most pathways CRYAB participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRYAB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein processing in endoplasmic reticulum | CAPN2,HSPA4L,MAP2K7,UGGT2,BCL2,HSPA2,ERLEC1,CAPN2L,HSPA5,UBE2G1 |
Protein Function
CRYAB has several biochemical functions, for example, identical protein binding,metal ion binding,microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CRYAB itself. We selected most functions CRYAB had, and list some proteins which have the same functions with CRYAB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | C9orf116,C2orf50,SIGLEC6,SLC4A4,POMP,PIK3CB,SPINK7,SCYL3,TSPO,RAB13 |
| metal ion binding | ASNA1,ZCCHC18,ZNF280D,NDUFS7,ZNF26,ZFP771,TNFRSF11A,MUL1A,ZNF136,PPP5C |
| unfolded protein binding | PFDN2,CHAF1A,MKKS,HSP104,CRYABB,DNAJB4,TTC1,CDC37L1,DNAJA1,HSPD1 |
| identical protein binding | LUC7L,SMAD6,GRIN3A,KCNJ2,SELK,USP15,TRIP13,NQO1,APIP,MMP9 |
| protein homodimerization activity | OSTA,HER5,GSTM7,SNX9,BCL2A1A,BCL11A,LMLN,C9orf142,PVALB,DHDPSL |
| microtubule binding | MID1,FNTA,TXNDC3,KIF17,KIF5AA,FTCD,GAS2L2,MAP1LC3C,ARL3,KIF16B |
| structural constituent of eye lens | CRYBB3,LIM2.1,LIM2,CRYAA,ASL2,CRYGN1,LIM2.2,CRYBA1,CRYGF,BFSP2 |
Interacting Protein
CRYAB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRYAB here. Most of them are supplied by our site. Hope this information will be useful for your research of CRYAB.
CRYAA;HSPB1;CRYGC
Resources
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References
- Campbell-Lloyd, AJM; Mundy, J; et al. Is Alpha-B Crystallin an Independent Marker for Prognosis in Lung Cancer?. HEART LUNG AND CIRCULATION 22:759-766(2013).
- Davidov, T; Nagar, M; et al. Carbonic anhydrase 4 and crystallin alpha-B immunoreactivity may distinguish benign from malignant thyroid nodules in patients with indeterminate thyroid cytology. JOURNAL OF SURGICAL RESEARCH 190:565-574(2014).
