Cry1

  • Official Full Name

    cryptochrome 1 (photolyase-like)
  • Overview

    Cryptochromes (from the Greek κρυπτ? χρ?μα, hidden colour) are a class of blue light-sensitive flavoproteins found in plants and animals. Cryptochromes are involved in the circadian rhythms of plants and animals, and in the sensing of magnetic fields in a number of species. The name Cryptochrome was proposed as a pun combining the cryptic nature of the photoreceptor, and the cryptogamic organisms on which many blue light studies were carried out. The two genes Cry1 and Cry2 code for the two cryptochrome proteins CRY1 and CRY2. In insects and plants, CRY1 regulates the circadian clock in a light-dependent fashion, whereas in mammals, CRY1 and CRY2 act as light-independent inhibitors of CLOCK-BMAL1 components of the circadian clock. In plants, blue light photoreception can be used to cue developmental signals
  • Synonyms

    CRY1;cryptochrome 1 (photolyase-like);PHLL1;cryptochrome-1;photolyase-like cryptochrome 1

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Rat
  • Mouse
  • Chicken
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cells
  • His
  • GST
  • Myc&DDK
  • Non
  • His&Fc&Avi
  • His&Myc
  • His&GST
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
CRY1-11596H Recombinant Human CRY1, His-tagged E.coli Human His 236-586a.a.
CRY1-1036R Recombinant Rhesus monkey CRY1 Protein, His-tagged Mammalian Cell Rhesus macaque His
CRY1-1608R Recombinant Rat CRY1 Protein Mammalian Cell Rat His
CRY1-1922H Recombinant Human CRY1 Protein, GST-tagged Wheat Germ Human GST
CRY1-3931M Recombinant Mouse CRY1 Protein Mammalian Cell Mouse His
CRY1-5818C Recombinant Chicken CRY1 Mammalian Cell Chicken His
CRY1-7269H Recombinant Human CRY1 protein, MYC/DDK-tagged HEK293 Human Myc&DDK
CRY1-7269HCL Recombinant Human CRY1 293 Cell Lysate HEK293 Human Non
CRY1-1266R Recombinant Rat CRY1 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
CRY1-1266R-B Recombinant Rat CRY1 Protein Pre-coupled Magnetic Beads HEK293 Rat
CRY1-1818H Recombinant Human CRY1 Protein (Val3-Leu132), N-GST tagged E.coli Human GST Val3-Leu132
CRY1-1993M Recombinant Mouse CRY1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
CRY1-1993M-B Recombinant Mouse CRY1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
CRY1-2082H Recombinant Human CRY1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human Myc&DDK
CRY1-2125HF Recombinant Full Length Human CRY1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 586 amino acids
Cry1-2323M Recombinant Mouse Cry1 Protein, Myc/DDK-tagged HEK293 Mouse Myc&DDK
CRY1-4422H Recombinant Human CRY1 protein, His&Myc-tagged E.coli Human His&Myc 1-586aa
CRY1-639H Recombinant Human CRY1 Protein, His/GST-tagged E.coli Human His&GST Val3~Leu132
CRY1-861R Recombinant Rhesus Macaque CRY1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
CRY1-861R-B Recombinant Rhesus Macaque CRY1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
CRY1-9037HFL Recombinant Full Length Human CRY1 protein, Flag-tagged Mammalian Cells Human Flag Full L.

    Involved Pathway

    Cry1 involved in several pathways and played different roles in them. We selected most pathways Cry1 participated on our site, such as BMAL1:CLOCK,NPAS2 activates circadian gene expression,Circadian Clock,Circadian rhythm, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cry1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    BMAL1:CLOCK,NPAS2 activates circadian gene expression NAMPT,CRY2,HELZ2,CARM1,NCOA2,DBP,NRIP1,CREBBP
    Circadian Clock CRY2,NAMPT,NRIP1,CSNK1E,HELZ2,CPT1A,CARM1,RAI1,DBP
    Circadian rhythm FBXW11,RORB,CUL1,PRKAA2,PER3,SKP1,RORC,BHLHE40,CRY2,RORA
    Diurnally regulated genes with circadian orthologs TOB1,ERC2,GFRA1,ZFR,PURA,CRY2,NR1D2,AZIN1,DAZAP2,KLF9

    Protein Function

    Cry1 has several biochemical functions, for example, NOT DNA (6-4) photolyase activity,DNA binding,blue light photoreceptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Cry1 itself. We selected most functions Cry1 had, and list some proteins which have the same functions with Cry1. You can find most of the proteins on our site.

    Function Related Protein
    blue light photoreceptor activity CRY2
    double-stranded DNA binding PNKP,KIN,HNRPDL,RBMS1,TARDBP,HMGB1,RAD51L1,TRP63,ZNF638,SP1
    NOT deoxyribodipyrimidine photo-lyase activity CRY2
    transcription factor activity, transcription factor binding TRP63,LDB1B,HIF1A,PER2,LDB2B,ASCL1,PER1,ASCL1B,TP63,LDB1A
    nuclear hormone receptor binding NCOR1,NCOA1,NRIP1,TCF7L2,CTNNB1,HIF1A,MYOD1,TACC2,CRX,ACTN4
    transcription factor binding PPP1R13B,JUN,TFDP2,FOXA3,PPARGC1A,H2-AB1,CSNK2B,IFT172,DDX3X,DNAJA3
    DNA binding GBX1,HUWE1,DNAJC2,ZBTB44,RUNX1T1,SRRT,ZFPM2,HOXA11B,MXTX2,ARID4A
    protein kinase binding CDH2,AURKA,AKAP7,PPP1R15A,MAPK6,SPDYE2,MAP3K13,RPS6KA3,XBP1,AP1B1
    phosphatase binding CTSC,KLRAQ1,SMAD2,PPP1R35,DZIP3,TRPC4AP,MAST2,MAPK3,MAPK1,TPRN

    Interacting Protein

    Cry1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cry1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Cry1.

    PLSCR1;CSNK1E;Cry1;Csnk1e;Timeless;GRN;SNRPD3;TRAF2;CBLB;LTBP4;MDFI;KRTAP4-12;Psmb5;SYNCRIP;BAG6;JAK3;Sesn2;Esrrb

    Resources

    References

    • Sha, S; Yin, Y; et al. A New Method for Immobilizing Antibody Probes in Immunochips Based on DNA Hybridization. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 41:199-204(2013).
    • Watari, R; Yamaguchi, C; et al. Light-dependent Structural Change of Chicken Retinal Cryptochrome4. JOURNAL OF BIOLOGICAL CHEMISTRY 287:42634-42641(2012).

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