COX4I1
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Official Full Name
cytochrome c oxidase subunit IV isoform 1 -
Overview
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3 of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. [provided by RefSeq, Jul 2008] -
Synonyms
COX4I1;cytochrome c oxidase subunit IV isoform 1;COX4;COXIV;COX4-1;cytochrome c oxidase subunit 4 isoform 1, mitochondrial;COX IV-1;cytochrome c oxidase polypeptide IV
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Chicken
- Rhesus macaque
- Bovine
- Wheat Germ
- Mammalian Cells
- HEK293
- E.coli
- In Vitro Cell Free System
- Non
- His
- GST
- Avi
- Fc
- SUMO
Involved Pathway
COX4I1 involved in several pathways and played different roles in them. We selected most pathways COX4I1 participated on our site, such as Alzheimers disease,Cardiac muscle contraction,Electron Transport Chain, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX4I1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alzheimers disease | CALML3,UQCRFS1,FADD,CASP12,BAD,ATP5F1,PPP3CA,SDHC,APBB1,NDUFA2 |
| Gene Expression | ZNF143A,HNRNPH1,AGO3B,ZNF331,PEAK1,CD3EAP,ZNF583,ZNF75A,HBXIP,IGF2BP3 |
| Huntingtons disease | POLR2H,POLR2I,NDUFA4L2,NDUFV1,GPX1,NDUFA13,CREB3L1,COX6B1,TP53,CREB3L3 |
| Metabolic pathways | ADH1,CYP2P6,ADI1,PAH,MTHFD1,AHCY,OLAH,SQLEA,CYP11B2,PCYT1AB |
| Metabolism | GYG1B,ELA2L,CYP2AD3,PCBD1,SLC35B2,GPHNA,ABHD4,ARSJ,GCHFR,ACOT8 |
| Electron Transport Chain | ATP5H,COX5B,NDUFS7,COX6C,SURF1,COX7A2,COX6A1,COX17,COX8A,ATP5L |
| Cardiac muscle contraction | COX7B2,UQCR10,TPM4A,ATP1A3,COX5AA,VMHC,TPM4B,CACNA1D,MYL4,COX6B2 |
| Generic Transcription Pathway | NRBF2B,NR2F1,HIPK1,ZNF10,ZNF573,COX6A1,ZNF615,ZNF697,NR1I2,ZNF562 |
Protein Function
COX4I1 has several biochemical functions, for example, cytochrome-c oxidase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COX4I1 itself. We selected most functions COX4I1 had, and list some proteins which have the same functions with COX4I1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RNF34,ST6GAL1,RERG,ARHGEF6,FYCO1,TMEM182,FAM108A1,ADAM33,RHOH,COPRS |
| cytochrome-c oxidase activity | COX7A1,COX7A2,SURF1,COX5B,COX5B2,CYB5A,COX6B2,COX7A2A,COX5AA,COX15 |
Interacting Protein
COX4I1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX4I1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COX4I1.
SDCBP;env;40038273;MT-CO1;MT-CO2;IKBKE;TMBIM4;env;HSPD1;TUBG1;JAK3;Smn1;COX6A2;MCL1;ICT1
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References
- Castelblanco, E; Gallel, P; et al. Thyroid paraganglioma. Report of 3 cases and description of an immunohistochemical profile useful in the differential diagnosis with medullary thyroid carcinoma, based on complementary DNA array results. HUMAN PATHOLOGY 43:1103-1112(2012).
- Arnold, S; et al. Cytochrome c Oxidase and Its Role in Neurodegeneration and Neuroprotection. MITOCHONDRIAL OXIDATIVE PHOSPHORYLATION: NUCLEAR-ENCODED GENES, ENZYME REGULATION, AND PATHOPHYSIOLOGY 748:305-339(2012).
