COPS8
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Official Full Name
COP9 signalosome subunit 8 -
Overview
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] -
Synonyms
COPS8;COP9 signalosome subunit 8;COP9;CSN8;SGN8;COP9 signalosome complex subunit 8;hCOP9;COP9 homolog;signalosome subunit 8;JAB1-containing signalosome subunit 8;COP9 constitutive photomorphogenic homolog subunit 8
Recombinant Proteins
- Zebrafish
- Rat
- Human
- Chicken
- Mouse
- Mammalian Cell
- Wheat Germ
- E.coli
- Human
- HEK293
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
COPS8 involved in several pathways and played different roles in them. We selected most pathways COPS8 participated on our site, such as DNA Damage Recognition in GG-NER,DNA Repair,Formation of TC-NER Pre-Incision Complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with COPS8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcription-Coupled Nucleotide Excision Repair (TC-NER) | KIAA1530,COPS2,COPS6,ERCC8,GPS1,PPIE,ZFP830,COPS7A,COPS4,COPS3 |
| DNA Repair | THRSP,COPS3,PPP4R2A,USP45,PARP2,RHNO1,FAM175A,RAD18,EME1,PNKP |
| Global Genome Nucleotide Excision Repair (GG-NER) | COPS3,ACTL6A,YY1A,DDB2,YY1,CHD1L,PIAS3,COPS2,COPS5,USP45 |
| DNA Damage Recognition in GG-NER | INO80,COPS7A,DDB1,COPS2,COPS4,GPS1,PARP2,INO80E,YY1,ACTL6A |
| Nucleotide Excision Repair | POLE2,RAD23AB,YY1,RFC1,XPC,COPS7A,GTF2H3-2,LIG1,GTF2H2C,COPS7B |
| Formation of TC-NER Pre-Incision Complex | COPS5,KIAA1530,ERCC8,COPS3,COPS4,TCEA1,COPS2,COPS7B,COPS6,ZNF830 |
Protein Function
COPS8 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COPS8 itself. We selected most functions COPS8 had, and list some proteins which have the same functions with COPS8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | EIF1AD,APOA4,MEP1B,VMP1,DSP,NATD1,C12orf49,ATP6V1H,RBFOX2,ETL4 |
Interacting Protein
COPS8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COPS8 here. Most of them are supplied by our site. Hope this information will be useful for your research of COPS8.
GFER;USHBP1;COPS5;CHM;COPS6;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;vpr;GPS1;CUL4B;BABAM1
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References
- Ma, XL; Xu, M; et al. Crystal structure of the human CSN6 MPN domain. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 453:25-30(2014).
- Pan, L; Wang, S; et al. Protein competition switches the function of COP9 from self-renewal to differentiation. NATURE 514:233-+(2014).
