COG8
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Official Full Name
component of oligomeric golgi complex 8 -
Overview
This gene encodes a protein that is a component of the conserved oligomeric Golgi (COG) complex, a multiprotein complex that plays a structural role in the Golgi apparatus, and is involved in intracellular membrane trafficking and glycoprotein modification. Mutations in this gene cause congenital disorder of glycosylation, type IIh, a disease that is characterized by under-glycosylated serum proteins, and whose symptoms include severe psychomotor retardation, failure to thrive, seizures, and dairy and wheat product intolerance. -
Synonyms
COG8;component of oligomeric golgi complex 8;conserved oligomeric Golgi complex subunit 8;DOR1;FLJ22315;COG complex subunit 8;Conserved oligomeric Golgi complex component 8 dependent on RIC1;dependent on RIC1;conserved oligomeric golgi complex component 8;CDG2H
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| COG8-11422H | Recombinant Human COG8, GST-tagged | E.coli | Human | GST | C-term-219a.a. | |
| COG8-1631H | Recombinant Human COG8 Protein, GST-tagged | Wheat Germ | Human | GST |
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| COG8-2176Z | Recombinant Zebrafish COG8 | Mammalian Cell | Zebrafish | His |
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| COG8-7381HCL | Recombinant Human COG8 293 Cell Lysate | HEK293 | Human | Non |
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| COG8-1641H | Recombinant Human COG8 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| COG8-2085HF | Recombinant Full Length Human COG8 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 219 amino acids |
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| Cog8-2240M | Recombinant Mouse Cog8 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
COG8 involved in several pathways and played different roles in them. We selected most pathways COG8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with COG8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
COG8 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COG8 itself. We selected most functions COG8 had, and list some proteins which have the same functions with COG8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | NFKBID,GOSR2,RNASE1,SURF1,GAD1,GNA13,SKIV2L2,UBE2L3,HSPA6,TARDBP |
Interacting Protein
COG8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COG8 here. Most of them are supplied by our site. Hope this information will be useful for your research of COG8.
GEM;MYEF2;sbcB;q81kr8_bacan;zapE;q8ix85_human;COG7;COG3;COG4
Resources
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References
- Liu, SC; Dominska-Ngowe, M; et al. Target silencing of components of the conserved oligomeric Golgi complex impairs HIV-1 replication. VIRUS RESEARCH 192:92-102(2014).
- Barone, R; Fiumara, A; et al. Congenital Disorders of Glycosylation with Emphasis on Cerebellar Involvement. SEMINARS IN NEUROLOGY 34:357-366(2014).
