CLEC4M
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Official Full Name
C-type lectin domain family 4, member M -
Overview
This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants. -
Synonyms
CLEC4M;C-type lectin domain family 4, member M;CD209L, CD299, CD299 antigen;C-type lectin domain family 4 member M;DC SIGN2;DC SIGNR;DCSIGNR;HP10347;LSIGN;C type lectin domain family 4, member M;CD209 antigen like;CD209 antigen like protein 1;CD209 antigen-like protein 1;CD209L;CD209L1;CD299;CD299 antigen;CLC4M_HUMAN;DC SIGN related protein;DC-SIGN-related protein;DC-SIGN2;DC-SIGNR;DCSIGN related protein;Dendritic cell-specific ICAM-3-grabbing non-integrin 2;L SIGN;L-SIGN;Liver/lymph node specific ICAM3 grabbing nonintegrin;Liver/lymph node-specific ICAM-3-grabbing non-integrin;Mannose binding C type lectin DC SIGNR;MGC129964;MGC47866;mannose binding C-type lectin DC-SIGNR;liver/lymph node-specific ICAM-3 grabbing non-integrin
Recombinant Proteins
- Human
- Human Cell
- Insect cell
- Mammalian cells
- Wheat Germ
- E.coli
- HEK293
- Human Cells
- HEK293T
- Fc
- His&Fc
- GST
- His&T7
- Non
- FC
- His
- His&Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CLEC4M involved in several pathways and played different roles in them. We selected most pathways CLEC4M participated on our site, such as Measles,Phagosome,Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLEC4M were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tuberculosis | IFNA12,TGFB1,IL18,LSP1,IFNA13,IL1B,IFNA21,PPP3R1,H2-AA,HLA-DPB1 |
| Measles | IL2RA,CD28,HSPA8,PRKCQ,CCNE1,MSN,PIK3R5,STAT5B,CD209,TNFRSF10C |
| Phagosome | CTSSA,HLA-DOB,HLA-B,ATP6V0A2,CALR,ATP6V0E,ATP6V1D,SEC22B,SEC61A1,ATP6V1E1 |
Protein Function
CLEC4M has several biochemical functions, for example, ICAM-3 receptor activity,calcium-dependent protein binding,carbohydrate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLEC4M itself. We selected most functions CLEC4M had, and list some proteins which have the same functions with CLEC4M. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium-dependent protein binding | SYT1,RAC3,DMBT1,ANXA3,ANXA11,ANXA2,MYO5A,CALM3,S100A6,SEC31A |
| ICAM-3 receptor activity | ITGB2,ITGAL |
| metal ion binding | DNMT3B,BCL11AA,ARAP2,SP1,AGBL4,ZDHHC15A,ACMSD,ZNF227,FRAS1,ANTXR1 |
| peptide antigen binding | TUBB3,MHC1UDA,TRGV3,MHC1UKA,HLA-E,MHC1UXA2,MHC1UJA,HLA-DRB5,TAPBP,DHCR24 |
| mannose binding | BSG,LMAN2,CD209,MBL2,CD209B,MBL1,LMAN2L,CD209C,CLN5,IGF2R |
| virus receptor activity | XPR1,HTR2A,SIVA1,TNFRSF14,CLDN1,TYRO3,SCARB1,ITGB1,TNFRSF4,SLC20A2 |
| carbohydrate binding | FCN3,NOMO3,LGALS3L,LGALS4,BCAN,MAG,CLEC10A,Cd24a,REG3B,GCKR |
| virion binding | HSP90B1,HIPK2,PPIA,CD209,PVRL1,PTX3,APCS,TSG101 |
| receptor activity | GRIA4B,KIR2DL3,Siglece,PROCR,MCC,GUCY1B3,FOLR1,AGER,CADM1A,Tnfrsf22 |
Interacting Protein
CLEC4M has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLEC4M here. Most of them are supplied by our site. Hope this information will be useful for your research of CLEC4M.
ITGAM;CEACAM1;q03463-pro_0000278734;MME
Resources
Research Area
Endothelial Cell MarkersCD Antigen (Dendritic Cell Pathogen Recognition Uptake)
C-type Lectin Receptors
Dendritic Cell Adhesion and Migration
Dendritic Cell Pathogen Recognition/Uptake
C-type Lectin Family
Related Services
Related Products
References
