CHRNA2
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Official Full Name
cholinergic receptor, nicotinic, alpha 2 (neuronal) -
Overview
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. -
Synonyms
CHRNA2;cholinergic receptor, nicotinic, alpha 2 (neuronal);cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal);neuronal acetylcholine receptor subunit alpha-2;ACHA2_HUMAN;Cholinergic receptor nicotinic alpha 2;Neuronal acetylcholine receptor protein subunit alpha 2
Recombinant Proteins
- Human
- Rat
- Mouse
- Chicken
- Wheat Germ
- Mammalian Cells
- E.coli
- HEK293
- GST
- His
- T7
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
CHRNA2 involved in several pathways and played different roles in them. We selected most pathways CHRNA2 participated on our site, such as Acetylcholine Binding And Downstream Events,Activation of Nicotinic Acetylcholine Receptors,Highly calcium permeable nicotinic acetylcholine receptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRNA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Acetylcholine Binding And Downstream Events | CHRNA4,CHRNA3,CHRNB4,CHRNB2,CHRND,CHRNE,CHRNA1,CHRNA5,CHRNA7 |
| Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | CHRNB2,CHRNA4,CHRNB4,CHRNA1,CHRNA5,CHRNA7,CHRNA3 |
| Highly calcium permeable nicotinic acetylcholine receptors | CHRNA3,CHRNA4,CHRNA1,CHRNB4,CHRNB2,CHRNA5 |
| Neuronal System | UNC13B,KCND1,STXBP1A,CAMKK1B,KCNN1A,KCNN2,MYO6,ARL6IP5,CHRNA5,SLC6A11 |
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | NSFA,NCALDA,MYO6,CHRND,PICK1,AKAP5,HAND2,NSFB,CAMKK1B,DLG1L |
| Activation of Nicotinic Acetylcholine Receptors | CHRNB2,CHRNA5,CHRNA7,CHRNA4,CHRNA1,CHRNA3,CHRNE,CHRND,CHRNB4 |
| Postsynaptic nicotinic acetylcholine receptors | CHRND,CHRNE |
| Neuroactive ligand-receptor interaction | CSH,GRID1,OPRD1,ADRA1BB,TAAR1B,LEPA,GABRR2,MC5RB,FPR3,GRIN2BB |
Protein Function
CHRNA2 has several biochemical functions, for example, contributes_to acetylcholine binding,acetylcholine receptor activity,acetylcholine-activated cation-selective channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRNA2 itself. We selected most functions CHRNA2 had, and list some proteins which have the same functions with CHRNA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| acetylcholine-activated cation-selective channel activity | CHRNB4,CHRNA1,CHRNB3B,CHRNA2A,CHRNB1L,CHRNB2,CHRNA4B,CHRNA3,CHRNA6,CHRNA7 |
| drug binding | NR1I2,HTR2A,HTR2C,DRD1A,FOLR2,HTR1B,CHRNB2,GLRB,NAMPT,FOLR1 |
| contributes_to acetylcholine binding | CHRNA3,CHRNB3A,CHRNA4B,CHRNA6,CHRNA5,CHRNA10A,CHRNB3B,CHRNA1,CHRND,CHRNA2A |
| acetylcholine receptor activity | CHRNB2,ANXA9,CHRNA3,CHRNA7,CHRNA6,CHRNB4,CHRNA5,CHRNE,CHRNA4 |
Interacting Protein
CHRNA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRNA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRNA2.
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References
- Kalashnyk, OM; Gergalova, GL; et al. Intracellular localization of nicotinic acetylcholine receptors in human cell lines. LIFE SCIENCES 91:1033-1037(2012).
- Govind, AP; Walsh, H; et al. Nicotine-Induced Upregulation of Native Neuronal Nicotinic Receptors Is Caused by Multiple Mechanisms. JOURNAL OF NEUROSCIENCE 32:2227-2238(2012).
