CHRM5
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Official Full Name
cholinergic receptor, muscarinic 5 -
Overview
The muscarinic acetylcholine receptor M5 is a member of the GPCR family (subfamily, acetylcholine) which mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. The rimary transducing effect is PI turnover. The receptor has been reported to be expressed in blood, brain, and ovary. ESTs have been isolated from human testis and placenta libraries. -
Synonyms
CHRM5;cholinergic receptor, muscarinic 5;HM5;MGC41838;muscarinic acetylcholine receptor M5;OTTHUMP00000159731
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- Rhesus macaque
- Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
- Mus musculus
- Macaca mulatta
- Pan troglodytes
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- E.coli
- E.coli expression system
- Non
- GST
- His
- His&Fc&Avi
- His&Flag
Involved Pathway
CHRM5 involved in several pathways and played different roles in them. We selected most pathways CHRM5 participated on our site, such as Amine ligand-binding receptors,Calcium Regulation in the Cardiac Cell,Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRM5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Amine ligand-binding receptors | DRD4,CHRM1,DRD5,CHRM4,CHRM2,CHRM3,ADRA1D,ADRA1B,ADRA2B,ADRa1A |
| G alpha (q) signalling events | HCRT,DGKB,DGKG,UTS2,NMB,NMBA,GPR4,LPAR2A,FPR-RS6,LPAR1 |
| GPCR downstream signaling | S1PR1,GCGB,GCGA,SST,RGS6,FFAR3,CYSLTR1,RXFP2,FPR-RS6,NPSR1 |
| Calcium signaling pathway | ATP2B1A,TNNC1,ATP2A2A,NTSR1,ORAI1B,CALM3B,ITPKC,ERBB2,SLC8A1B,PPP3CA |
| Cholinergic synapse | CHRNA7,GNAQ,KCNQ5,CREB3L2,FYN,ACHE,MAPK1,GNG2,PIK3R2,GNG12 |
| Class A/1 (Rhodopsin-like receptors) | CCL27,NTS,NMBB,TAC2,OPN1SW,OXGR1A.1,OPN4,AMCF-II,CXCL11.8,LPAR2B |
| Calcium Regulation in the Cardiac Cell | ADRB1,GJB4,PKIG,RGS4,RGS11,GJC1,GNG13B,RGS18,GNB3B,CHRM2 |
| GPCR ligand binding | OPN1MW,QRFPR,CNR2,NPFF,GPR37L1,CX3CR1,XK,GPBAR1,PNOC,SSTR4 |
Protein Function
CHRM5 has several biochemical functions, for example, G-protein coupled acetylcholine receptor activity,phosphatidylinositol phospholipase C activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRM5 itself. We selected most functions CHRM5 had, and list some proteins which have the same functions with CHRM5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidylinositol phospholipase C activity | PLCD3,PLD4,PLCB4,EDNRA,CCL5,BDKRB2,CCR5,CASR,PLCE1,PLCH2 |
| G-protein coupled acetylcholine receptor activity | CHRM4,CHRM2A,CHRM2,CHRM3,CHRM1,CHRM5A,CHRM5B |
Interacting Protein
CHRM5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRM5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRM5.
Resources
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References
- Meixner, M; Atanasova, S; et al. Expression of Acetylcholine Receptors by Experimental Rat Renal Allografts. BIOMED RESEARCH INTERNATIONAL :-(2014).
- Lin, HJ; Wan, L; et al. Muscarinic Acetylcholine Receptor 3 Is Dominant in Myopia Progression. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 53:6519-6525(2012).
