CENPB
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Official Full Name
centromere protein B, 80kDa -
Overview
This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. [provided by RefSeq, Jul 2008] -
Synonyms
CENPB;centromere protein B, 80kDa;major centromere autoantigen B;CENP-B;centromere autoantigen B
Recombinant Proteins
- Human
- Mouse
- Wheat Germ
- Insect Cells
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- E.coli
- GST
- His
- Non
- His&Fc&Avi
- N-MBP & C-His
- Myc&DDK
- Flag
Involved Pathway
CENPB involved in several pathways and played different roles in them. We selected most pathways CENPB participated on our site, such as FOXM1 transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with CENPB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| FOXM1 transcription factor network | AURKB,CENPA,CKS1B,CHEK2,FOXM1 |
Protein Function
CENPB has several biochemical functions, for example, centromeric DNA binding,chromatin binding,satellite DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CENPB itself. We selected most functions CENPB had, and list some proteins which have the same functions with CENPB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| satellite DNA binding | MLH3,MBD4 |
| chromatin binding | EWSR1A,FANCM,CDK9,KLHDC3,JARID2,TOX,SNAI2,SP140,RDBP,SIN3A |
| sequence-specific DNA binding | HOXC5,POU5F1,PRRX1A,POUV,VDR,NKX3.3,ZNF215,ASCL1A,TCF7L2,HOXD12A |
| centromeric DNA binding | ZW10,MSH3,KIF2C,CENPC1,MSH2,MLH3 |
Interacting Protein
CENPB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CENPB here. Most of them are supplied by our site. Hope this information will be useful for your research of CENPB.
NR3C1;ETS1;NR4A1;OPTN;TAF1D;TK1;ANXA7;TAC1;GADD45A;CDKN1A;GSK3B;CSNK2B;PIN1;SMN1;GFI1B;SH2D3A;RPS6KA6;Cenpe;KIF20A;CDC25B
Resources
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References
- Marshall, OJ; Choo, KHA; et al. Putative CENP-B paralogues are not present at mammalian centromeres. CHROMOSOMA 121:169-179(2012).
- Low, AHL; Wong, S; et al. Evaluation of a new multi-parallel line immunoassay for systemic sclerosis-associated antibodies in an Asian population. RHEUMATOLOGY 51:1465-1470(2012).
