CDH5
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Official Full Name
cadherin 5, type 2 (vascular endothelium) -
Overview
This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined. -
Synonyms
CDH5;cadherin 5, type 2 (vascular endothelium);7B4;CD144;cadherin-5;7B4 antigen;VE-cadherin;cd144 antigen;endothelial-specific cadherin;vascular endothelial cadherin;cadherin 5, type 2, VE-cadherin (vascular epithelium)
Recombinant Proteins
- Mouse
- Human
- Zebrafish
- Rhesus macaque
- Chicken
- Rat
- Mus musculus
- Sus scrofa (Pig)
- HEK293
- E.coli
- Mammalian Cells
- Wheat Germ
- Insect Cells
- Human Cells
- His
- His&Fc
- GST
- Fc
- Non
- hIgG4
- His&T7
- His&Fc&Avi
Involved Pathway
CDH5 involved in several pathways and played different roles in them. We selected most pathways CDH5 participated on our site, such as Adherens junctions interactions,Cell adhesion molecules (CAMs),Cell junction organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell adhesion molecules (CAMs) | CLDN7B,PTPRF,SELL,PTPRM,CLDN11,CD2,VTCN1,ICOS,CLDN3,Siglec1 |
| Cell-Cell communication | FERMT2,RSU1,SKAP2,NPHS1,CDH11,F11R.2,DCC,CLDN3,CDH4,CDH7 |
| Signal Transduction | ACVR1C,NET1,RHPN2,CDON,NMU,RNF31,WIPF2,RGS7,AMOTL2B,CRHR2 |
| Cell junction organization | CDH9,CDH10,CD151,COL17A1,PLEC,CDH12A,CDH17,CLDN3,JUPA,PVRL2L |
| Leukocyte transendothelial migration | RASSF5,Itgam&Itgb2,CTNNA3,PIK3R5,PIK3CB,PIK3R2,CLDN11,CLDN1,PXN,ACTN2 |
| Adherens junctions interactions | JUP,CDH9,CDH8,ANG,PTBP3,CTNND1,CADM2,CDH12,CDH10A,PVRL1A |
| Cell-cell junction organization | CDH17,PVRL2L,CDH24,CDH12A,CDH6,CLDN20,CLDN4,CADM2,CLDN16,CDH8 |
Protein Function
CDH5 has several biochemical functions, for example, beta-catenin binding,calcium ion binding,ion channel binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH5 itself. We selected most functions CDH5 had, and list some proteins which have the same functions with CDH5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ion channel binding | KCNE2,PPP1R9B,KCNJ11,CIB1,KCNIP2,HTT,PKP2,SLC8A1,RIMS3,KCNB1 |
| calcium ion binding | CASQ1A,DSG1A,CBLB,NELL2,S100P,PCDH2G3,HSP90B1,DLL1,MACF1,ANXA1 |
| beta-catenin binding | DVL3,CHD8,TCF7,AXIN1,CDH1,LZTS2A,KLF4,NUMB,ESR1,PROP1 |
| receptor binding | PEX14,CROT,LHB,TNFSF18,HLA-G,KCNJ10,PLA2G1B,EDN3,NMU,DDX54 |
| protein phosphatase binding | MAP3K5,CSK,SNX3,SKAP1,PPP6R1,MVP,TRP53,AP3B1,VCP,CDKN1B |
| protein binding | TPR,ZFYVE20,RNF20,ZNF193,STX7,POLM,SMAD1,PPP2R5B,CASC3,BIRC5 |
Interacting Protein
CDH5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH5.
CTNNB1;PARD6A;KDR;PARD3;SHC1;Ctnnd1
Resources
Research Area
Endothelial Cell MarkersCardiac Stem Cell Markers
Hemangioblast Markers
Myogenesis Markers
Other CD Antigen
Endothelial Cell Differentiation Markers
Adherens Junction Proteins in Endothelial Cells
Adherens Junction Proteins in VSMC
Cadherin Superfamily
Smooth Muscle Cell Markers
Mesodermal Lineage Markers
Cadherins
Related Services
Related Products
References
