CCR7
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Official Full Name
chemokine (C-C motif) receptor 7 -
Overview
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. -
Synonyms
CCR7;chemokine (C-C motif) receptor 7;CMKBR7, EBI1;C-C chemokine receptor type 7;BLR2;CD197;CDw197;CCR-7;CC-CKR-7;C-C CKR-7;MIP-3 beta receptor;CC chemokine receptor 7;chemokine (C-C) receptor 7;Epstein-Barr virus induced gene 1;EBV-induced G protein-coupled receptor 1;EBV-induced G-protein coupled receptor 1;Epstein-Barr virus induced G-protein coupled receptor;lymphocyte-specific G protein-coupled peptide receptor;epstein-Barr virus-induced G-protein coupled receptor 1;EBI1;CMKBR7
Recombinant Proteins
- Human
- Cynomolgus
- Chicken
- Zebrafish
- Rhesus macaque
- Mouse
- Mus musculus
- HEK293
- Wheat Germ
- Mammalian Cell
- E.coli
- Human Cells
- In Vitro Cell Free System
- HEK293T
- Mammalian cells
- E.coli expression system
- His
- Non
- His&Flag
- His&Myc
- His&Fc&Avi
- Myc&DDK
- Fc
- Flag
Involved Pathway
CCR7 involved in several pathways and played different roles in them. We selected most pathways CCR7 participated on our site, such as Chemokine receptors bind chemokines,Chemokine signaling pathway,Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with CCR7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| G alpha (i) signalling events | CHRM4,RGS14,POMCB,OPN1MW2,NMU,PENKB,S1PR1,CCL35.2,OPN1LW,AGT |
| GPCRs, Class A Rhodopsin-like | APLNR,CCRL2,GPR17,CCBP2,SSTR3,CCR3,AGTR2,FFAR3,OPN1MW2,GPR63 |
| Chemokine signaling pathway | SHC3,PF4,GRK4,HRAS,CCL13,HCK,GM13304,CCL3L1,PRKCZ,PLCB4 |
| GPCR downstream signaling | NPFFR2,ADRA2A,RGS14,RGS21,OPN5,QRFPR,GPR132B,CXCL13,PTHLH,ARHGEF3 |
| Chemokine receptors bind chemokines | CCR9,CX3CR1,CCR3,AMCF-II,CCBP2,CXCR7B,CXCL11.8,CCL19A.2,CCR8,CCR5 |
| Cytokine-cytokine receptor interaction | ACVR1L,TNFRSF1A,CXCR1,EDA2R,KITB,OSM,PDGFC,CCL4,CCL5,IL12RB2 |
| GPCR ligand binding | RCA2.1,CRHR1,GPR65,OPN1MW2,FZD10,EMR3,GRP,GPBAR1,ACKR4,PMCH |
| Class A/1 (Rhodopsin-like receptors) | NPSR1,FPR-RS4,APLN,RXFP2,SSTR4,GPR31B,NPS,OPN5,CNR1,SSTR1 |
Protein Function
CCR7 has several biochemical functions, for example, C-C chemokine receptor activity,C-C motif chemokine 19 receptor activity,C-C motif chemokine 21 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCR7 itself. We selected most functions CCR7 had, and list some proteins which have the same functions with CCR7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor activity | OPN1MW,CCR10,OR51B5,GPR149,OLFR1013,OR3A2,FZD9,TAAR7A,ADRA1BB,PARAPINOPSINB |
| C-C chemokine receptor activity | CCR9,CCBP2,CCR6,CCR8,CCR3,CCR6A,CCR1,CCR10,CCR5,CCR1L1 |
Interacting Protein
CCR7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCR7 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCR7.
Resources
Research Area
Cytokine and Growth Factor Receptors on VSMCChemokine Receptors
Cytotoxic T Cells (CTLs)
Regulatory T Cells (Tregs)
T Cell Migration
T Follicular Helper (Tfh) Cells
CC Chemokine Receptors
Dendritic Cell Adhesion and Migration
Related Services
Related Products
References
- Jensen, SS; Hartling, HJ; et al. HIV-Specific ADCC Improves After Antiretroviral Therapy and Correlates With Normalization of the NK Cell Phenotype. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES 68:103-111(2015).
- Stepensky, P; Rensing-Ehl, A; et al. Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency. BLOOD 125:753-761(2015).
