CCL15
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Official Full Name
chemokine (C-C motif) ligand 15 -
Overview
Chemokine CC-2 (CCL15) is a small cytokine belonging to the CC chemokine family that is also known as leukotactin-1, MIP5 and HCC-2. CCL15 is expressed in liver, small intestine, colon, and in certain leukocytes and macrophages of the lung. It is chemotactic for neutrophils, monocytes, and lymphocytes and elicits its effects by binding to cell surface chemokine receptors like CCR1 and CCR3. The human CCL15 gene spans four exons and is located in a head-to-tail orientation on chromosome 17 with the gene of another CC chemokine known as CCL14. -
Synonyms
LKN1;NCC3;SY15;HCC-2;Lkn-1;MIP-5;NCC-3;SCYL3;MIP-1d;SCYA15;HMRP-2B;chemokine (C-C motif) ligand 15;CCL15_HUMAN;MIP5;C-C motif chemokine 15 [Precursor];Small-inducible cytokine A15;Macrophage inflammatory protein 5;Chemokine CC-2;MIP-1delta;Leukotactin-1;Mrp-2b;small inducible cytokine subfamily A (Cys-Cys), member 15;CCL15
Recombinant Proteins
- Human
- E.coli
- Wheat Germ
- HEK293
- Human Cells
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Non
- Flag
- Myc&DDK
Involved Pathway
CCL15 involved in several pathways and played different roles in them. We selected most pathways CCL15 participated on our site, such as Cytokine-cytokine receptor interaction,Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemokine signaling pathway | CCL11,CXCL16,CCL28,GNAI3,PPBP,PF4,NFKBIA,PIK3CA,CXCL8,CCL4L1 |
| Cytokine-cytokine receptor interaction | NGFR,CXCR3.1,CXCL9,Ifna11,CCL27B,XCL2,CSF2RA,CSF3R,TNFRSF18,TNFRSF1B |
Protein Function
CCL15 has several biochemical functions, for example, CCR chemokine receptor binding,chemoattractant activity,chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL15 itself. We selected most functions CCL15 had, and list some proteins which have the same functions with CCL15. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heparin binding | PCOLCE2,VEGFAA,ITGAM,PGF,WISP1,ABI3BP,ADAMTS3,ELANE,LPL,CFH |
| CCR chemokine receptor binding | CCL34B.1,CCL16,CCL19,XCL2,CCL22,CCL20A.3,XCL1,CCL3L3,CCL34A.4,CX3CL1 |
| chemokine activity | CCL13,CCL26,PF4,CCL35.1,CX3CL1,CXCL2,CXCL11.8,CCL19B,XCL1,CCL35.2 |
| chemoattractant activity | NTF3,FGF10,CCL3,PDGFB,HMGB2,VEGFA,VHL,CXCL12B,FIGF,FGF2 |
| receptor binding | Icosl,EHHADH,POMC,CNPY3,ZAP70,LBP,DECR2,A2M,PVRL2,HAO2 |
Interacting Protein
CCL15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL15 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL15.
Resources
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References
- Ahlberg, V; Bengtsson, KL; et al. Global transcriptional response to ISCOM-Matrix adjuvant at the site of administration and in the draining lymph node early after intramuscular injection in pigs. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 38:17-26(2012).
- Lechner, CJ; Gantin, RG; et al. Chemokines and cytokines in patients with an occult Onchocerca volvulus infection. MICROBES AND INFECTION 14:438-446(2012).
