CARD16
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Official Full Name
caspase recruitment domain family, member 16 -
Overview
Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. -
Synonyms
CARD16;caspase recruitment domain family, member 16;caspase recruitment domain-containing protein 16;COP;COP1;PSEUDO ICE;PSEUDO-ICE;CARD only domain-containing protein 1;CARD only protein;Caspase-1 dominant-negative inhibitor pseudo-ICE;Caspase-1 inhibitor COP;Pseudo interleukin-1 beta converting enzyme;Pseudo interleukin-1beta converting enzyme;OTTHUMP00000232049;OTTHUMP00000232050;c
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CARD16-1690H | Recombinant Human CARD16 Protein, GST-tagged | Wheat Germ | Human | GST |
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| CARD16-7848HCL | Recombinant Human CARD16 293 Cell Lysate | HEK293 | Human | Non |
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| CARD16-7849HCL | Recombinant Human CARD16 293 Cell Lysate | HEK293 | Human | Non |
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| CARD16-1950HF | Recombinant Full Length Human CARD16 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 97 amino acids |
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| CARD16-2523H | Recombinant Human CARD16 Protein, His-tagged | E.coli | Human | His |
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| CARD16-6035H | Recombinant Human CARD16 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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Involved Pathway
CARD16 involved in several pathways and played different roles in them. We selected most pathways CARD16 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CARD16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
CARD16 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CARD16 itself. We selected most functions CARD16 had, and list some proteins which have the same functions with CARD16. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cysteine-type endopeptidase inhibitor activity | CARD17,CST6,BIRC5B,NLRC4,CST7,CST2,WFDC2,AHSG,CST4,KNG1 |
Interacting Protein
CARD16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CARD16 here. Most of them are supplied by our site. Hope this information will be useful for your research of CARD16.
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References
- Cui, J; Chen, YJ; et al. Mechanisms and pathways of innate immune activation and regulation in health and cancer. HUMAN VACCINES & IMMUNOTHERAPEUTICS 10:3270-3285(2014).
- Voruganti, VS; Laston, S; et al. Genome-wide association replicates the association of Duffy antigen receptor for chemokines (DARC) polymorphisms with serum monocyte chemoattractant protein-1 (MCP-1) levels in Hispanic children. CYTOKINE 60:634-638(2012).
