Car9
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Official Full Name
carbonic anhydrase 9 -
Overview
CAIX is a transmembrane protein structurally consisting of a signal peptide, a proteoglycan-related region, a CA domain with a highly conserved active site, a transmembrane anchor and an intracytoplasmic tail, and is the only tumor-associated CA isoenzyme known so far. Compared with normal tissues, CAIX is overexpressed in a wide spectrum of tumor types and associated with increased metastasis and poor prognosis in aggressive carcinomas. CAIX expression is cell density dependent and has been shown to be strongly induced by hypoxia, accordingly facilitates adaptation of tumor cells to hypoxic conditions. CA9 is regarded as a new therapeutic target for CA9-derived carcinomas. -
Synonyms
Ca9;CAIX;MN/CA9
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Car9-914M | Recombinant Mouse Car9 protein(Met1-Asp390), His-tagged | HEK293 | Mouse | His | 1-390 a.a. |
Involved Pathway
Car9 involved in several pathways and played different roles in them. We selected most pathways Car9 participated on our site, such as Nitrogen metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with Car9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nitrogen metabolism | GLULC,GLUD1B,Car12,CA14,CAR13,CPS1,CA5A,CA13,GLULB,GLUL |
Protein Function
Car9 has several biochemical functions, for example, carbonate dehydratase activity,lyase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Car9 itself. We selected most functions Car9 had, and list some proteins which have the same functions with Car9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lyase activity | CAR3,TYW1B,ALDOCB,GC3,CBSA,GUCY2F,POLL,ADCY1B,URAD,PDXDC1 |
| metal ion binding | FOXP4,Itgam&Itgb2,GRIN2A,ZNF550,BMPR1B,ZNHIT2,KDM3B,ZMYM2,ZNF350,GNAI2 |
| zinc ion binding | ADAMTS13,CXXC1,RAG1,RNF144A,GATA2B,BMP1B,MID2,TTF2,MYNN,LPP |
| carbonate dehydratase activity | CA9,CA4B,CA6,Car12,CA5A,CA3,CAR1,CA2,CAR13,CA4 |
Interacting Protein
Car9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Car9 here. Most of them are supplied by our site. Hope this information will be useful for your research of Car9.
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