CAPZB

  • Official Full Name

    capping protein (actin filament) muscle Z-line, beta

  • Overview

    F-actin-capping-protein subunit beta (CapZ beta) belongs to the F-actin capping protein family, which are characteristic heterodimers, consisting of a α subunit (31-36 kDa) and a β subunit (28-32 kDa), that cap the barbed end of actin filaments within all eukaryotes. Their ability to bind the actin filaments is in a manner independent of Ca2++ and requires the C-terminal end of both subunits for optimal binding. F-actin capping protein subunit beta is contained within the Z-discs of striated muscle, where it functions to inhibit the polymerization and depolymerization of actin. Within vertebrates, there are three isoforms for each of F-actin capping protein subunit beta’s subunits. While there is almost nothing known regarding the β3 subunit, the β1 and β2 isoforms each have distinct role. The isoform β2 is predominantly expressed in non-muscle cells and is found in intercalated discs and the cell periphery, but is not observed at Z-discs. Isoform β1 is more greatly expressed in striated muscle and is localized at the Z-discs. It also contains the COOH-terminal extension necessary for capping the actin.

  • Synonyms

    CAPZB;capping protein (actin filament) muscle Z-line, beta;F-actin-capping protein subunit beta;capZ beta;CAPB;CAPZ;CAPPB;FLJ12274;FLJ44693;MGC104401;MGC129749;MGC129750;DKFZp686K0524

Recombinant Proteins

  • Human
  • Zebrafish
  • Rat
  • Chicken
  • E.coli
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • In Vitro Cell Free System
  • HEK293T
  • His
  • GST
  • Non
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
CAPZB-10717H Recombinant Human CAPZB, His-tagged E.coli Human His 2-243a.a.
CAPZB-0388H Recombinant Human CAPZB Protein, GST-Tagged Wheat Germ Human GST
CAPZB-10302Z Recombinant Zebrafish CAPZB Mammalian Cell Zebrafish His
CAPZB-1130R Recombinant Rat CAPZB Protein Mammalian Cell Rat His
CAPZB-26238TH Recombinant Human CAPZB, His-tagged E.coli Human His Full L. 1-272 a.a.
CAPZB-4072C Recombinant Chicken CAPZB Mammalian Cell Chicken His
CAPZB-6987C Recombinant Chicken CAPZB Mammalian Cell Chicken His
CAPZB-281HCL Recombinant Human CAPZB cell lysate Human Non
CAPZB-2484H Recombinant Human CAPZB Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
CAPZB-2633H Recombinant Human CAPZB protein, GST-tagged E.coli Human GST 1-272aa
CAPZB-2854HF Recombinant Full Length Human CAPZB Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 79 amino acids
CAPZB-4706H Recombinant Human CAPZB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
CAPZB-794R Recombinant Rat CAPZB Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
CAPZB-794R-B Recombinant Rat CAPZB Protein Pre-coupled Magnetic Beads HEK293 Rat

    Involved Pathway

    CAPZB involved in several pathways and played different roles in them. We selected most pathways CAPZB participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAPZB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endocytosis GBF1,IST1,ERBB3,ADRBK2,SH3GL3,GRK4,RET,LDLRAP1B,ARF3,RAB11FIP3

    Protein Function

    CAPZB has several biochemical functions, for example, actin binding,actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CAPZB itself. We selected most functions CAPZB had, and list some proteins which have the same functions with CAPZB. You can find most of the proteins on our site.

    Function Related Protein
    actin binding HIP1RB,LIMCH1A,VPS16,SCIN,EPB41L3A,TRPV4,GCSAM,TNNT2A,PPP1R9B,PTK2
    actin filament binding DBNLA,SVILA,WIPF3,FLNA,SHROOM2,MYO6,MYO1A,FSCN1A,MYO10,MICALL2

    Interacting Protein

    CAPZB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAPZB here. Most of them are supplied by our site. Hope this information will be useful for your research of CAPZB.

    VCAM1;GH1;MCC;DMWD;IKBKE;TWF2;UIMC1;MAP3K3;TRAF6;RIPK3;RPP14;PTN;dcyD;mfd;MRPL20

    Resources

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