CACNA2D1
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Official Full Name
calcium channel, voltage-dependent, alpha 2/delta subunit 1 -
Overview
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. -
Synonyms
CACNA2D1;calcium channel, voltage-dependent, alpha 2/delta subunit 1;CACNA2, CACNL2A, MHS3;voltage-dependent calcium channel subunit alpha-2/delta-1;calcium channel, L type, alpha 2 polypeptide;voltage-gated calcium channel subunit alpha-2/delta-1;d
Recombinant Proteins
- Human
- Mouse
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- Yeast
- GST
- His
- SUMO
- Trx
- Avi
- Fc
Involved Pathway
CACNA2D1 involved in several pathways and played different roles in them. We selected most pathways CACNA2D1 participated on our site, such as MAPK signaling pathway,Cardiac muscle contraction,Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNA2D1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cardiac muscle contraction | COX5A,ATP1A3B,CACNB4A,SLC8A1,CACNG7A,CACNA2D4,COX7A2,VMHCL,CACNG2,TNNT2A |
| Hypertrophic cardiomyopathy (HCM) | ITGAV,PRKAG2,MYL3,ITGA9,ITGA2,ITGA5,SGCD,SGCG,ACTC1,DES |
| Dilated cardiomyopathy | CACNG2,TPM4,CACNG8,ITGA10,SGCD,TTN,TPM2,Itga10&Itgb1,EMD,ITGA4 |
| MAPK signaling pathway | PRKCA,GRB2A,FGF11A,MAP3K7,RPS6KA3,HSPA1L,MAX,MEF2C,FGF8,TGFBR1B |
| Adrenergic signaling in cardiomyocytes | ATP1B3,CALM4,PLCB1,ADCY8,CAMK2D,ADRB3A,SLC14A2,PPP2R5D,ADRa1A,CALM2B |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ITGA7,ITGA5,DAG1,ITGB1,ACTN3,CACNB1,ITGB3,LMNA,CTNNA3,SGCB |
| Oxytocin signaling pathway | RAF1,PLA2G4C,CAMK1,PLCB3,CAMK2G,PPP1CA,PRKAA2,ELK1,ITPR3,ITPR1 |
Protein Function
CACNA2D1 has several biochemical functions, for example, calcium channel regulator activity,metal ion binding,voltage-gated calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNA2D1 itself. We selected most functions CACNA2D1 had, and list some proteins which have the same functions with CACNA2D1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| voltage-gated calcium channel activity | RYR1,NCS1,TPC3,CACNB4A,CALHM1,CATSPER1,CACNB4B,CACNG1,CACNA1C,CACNG2B |
| calcium channel regulator activity | GRM2,TSPAN13B,NRXN2,NRXN1,TSPAN13,NPY,NPY2R,SGK2A,SGK1,GNB2 |
| contributes_to voltage-gated calcium channel activity | CACNB3,CACNB4 |
| metal ion binding | ZNF668,PPM1G,ZFP57,ZNF563,FHL1A,CRBN,TRIM35-27,ITGA1,ZNF544,KLF14 |
Interacting Protein
CACNA2D1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNA2D1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNA2D1.
Baz2b;MYH7B;Calu;Itgb1;Plk2;HNRNPU;Ccdc77;CNOT2
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