BNIP3
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Official Full Name
BCL2/adenovirus E1B interacting protein 3 -
Overview
BNIP3 (Bcl-2/E1B-19kDa interacting protein 3) is a pro-apoptotic mitochondrial protein and Bcl-2 family member that contains a Bcl-2 homology 3 (BH3) domain and a carboxyl terminal transmembrane (TM) domain. While BNIP3 has a predicted molecular weight of -
Synonyms
BNIP3;BCL2/adenovirus E1B interacting protein 3;BCL2/adenovirus E1B 19 kDa protein-interacting protein 3;BCL2/adenovirus E1B interacting protein 1, NIP3;BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP3;BCL2/adenovirus E1B 19 kDa-interacting prot
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rat
- Bovine
- Mus musculus
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In vitro E. coli expression system
- In Vitro Cell Free System
- E.coli expression system
- His
- GST
- Non
- His&Fc&Avi
- His&GST
Involved Pathway
BNIP3 involved in several pathways and played different roles in them. We selected most pathways BNIP3 participated on our site, such as FoxO signaling pathway,Legionellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with BNIP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| FoxO signaling pathway | SMAD3,MAPK11,PCK1,HOMER1,HOMER2,PTENB,CCND1,ATG12,MAPK8,CCND2 |
| Legionellosis | CASP1,IL1B,HBS1L,NFKB1,EEF1A2,CXCL1,TLR2,HSPA1A,ITGB2,PYCARD |
Protein Function
BNIP3 has several biochemical functions, for example, GTPase binding,identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BNIP3 itself. We selected most functions BNIP3 had, and list some proteins which have the same functions with BNIP3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PLK3,SOX17,ATP7B,MUL1,THOC5,IFI16,CCDC112,TMPRSS4,PDXP,CNPY2 |
| protein heterodimerization activity | IKBKG,MYF6,TWIST1,BAD,UGT1A9,ATF3,SMAD1,HIST1H2AL,YWHAE,CLCF1 |
| GTPase binding | SPTBN1,AIMP1,LCP1,PTPRN,EPRS,GM5506,HSP90AA1,GOLGA4,GNB2,ENO1 |
| protein homodimerization activity | MGLL,UPK1A,CALCOCO2,TREX2,STK25,LMLN,CRTAM,PDGFRA,SMAGP,CCBL2 |
| identical protein binding | BIN1,ADORA2A,VEGFA,ACPP,SH3GLB1,BCHE,AXIN1,HSD17B10,DYNLT1B,PNMA5 |
Interacting Protein
BNIP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BNIP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of BNIP3.
BNIP3L;TMEM11
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References
- Zhang, XS; Bian, XW; et al. The Proapoptotic Protein BNIP3 Interacts with VDAC to Induce Mitochondrial Release of Endonuclease G. PLOS ONE 9:-(2014).
- Awan, MUF; Hasan, M; et al. Neuroprotective role of BNIP3 under oxidative stress through autophagy in neuroblastoma cells. MOLECULAR BIOLOGY REPORTS 41:5729-5734(2014).
