B4GALT4
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Official Full Name
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 -
Overview
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene appears to mainly play a role in glycolipid biosynthesis. Two alternatively spliced transcript variants have been found for this gene. -
Synonyms
B4GALT4;UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4;beta-1,4-galactosyltransferase 4;beta4Gal T4;B4Gal T4;Beta 1 4 galactosyltransferase 4;Beta 1 4 GalTase 4;Beta N acetylglucosaminyl glycolipid beta 1 4 galactosyltransferase 4;EC 2.4.1.-;UDP Gal:betaGlcNAc beta,4 galactosyltransferase 4;UDP Gal:betaGlcNAc beta 1 4 galactosyltransferase polypeptide 4;UDP galactose:beta N acetylglucosamine beta 1 4 galactosyltransferase 4;beta-1,4-GalTase 4;UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4;UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase 4;beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase 4;UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4;B4Gal-T4;beta4Gal-T4
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Mouse
- Wheat Germ
- Mammalian Cell
- E.coli
- HEK293
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- E.coli expression system
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
B4GALT4 involved in several pathways and played different roles in them. We selected most pathways B4GALT4 participated on our site, such as Glycosaminoglycan biosynthesis - keratan sulfate,Glycosphingolipid biosynthesis - lacto and neolacto series,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with B4GALT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | CSAD,DTYMK,SMS,GBA,PLD3,CPOX,AMPD2,CYCSB,GUK1A,MGAT4B |
| Glycosaminoglycan biosynthesis - keratan sulfate | B3GNT7,ST3GAL2,FUT8A,B4GALT3,B3GNT2B,B3GNT2,B3GNT1,ST3GAL3,B4GALT1,Chst5 |
| Glycosphingolipid biosynthesis - lacto and neolacto series | FUT2,FUT5,B3GALT1,FUT6,FUT9A,B3GNT4,B3GNT5B,ABO,B3GNT5,FUT1 |
Protein Function
B4GALT4 has several biochemical functions, for example, N-acetyllactosamine synthase activity,galactosyltransferase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by B4GALT4 itself. We selected most functions B4GALT4 had, and list some proteins which have the same functions with B4GALT4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| galactosyltransferase activity | B4GALT7,C1GALT1,GLT8D1,B4GALT2,GALNTL4,B3GNT6,B3GNT4,UGGT1,GTDC2,B3GALNT2 |
| N-acetyllactosamine synthase activity | B4GALT3,B4GALT2,B4GALT1 |
| metal ion binding | PRDM9,ZSCAN16,COL10A1,KSR2,ZBTB5,KDM4D,KLK4,OVOL3,SNAI1B,NRXN3A |
Interacting Protein
B4GALT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with B4GALT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of B4GALT4.
Psmb5;Tubg1
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