ATP4B
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Official Full Name
ATPase, H+/K+ exchanging, beta polypeptide -
Overview
The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase;is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated;beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and;K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta;subunit of the gastric H+, K+-ATPase. -
Synonyms
ATP4B;ATPase, H+/K+ exchanging, beta polypeptide;potassium-transporting ATPase subunit beta;ATP6B;Gastric H(+)/K(+) ATPase subunit beta;ATPase H+/K+ exchanging beta polypeptide;ATPase H+/K+ transporting beta polypeptide;Gastric H K ATPase catalytic subunit;Gastric H+/K+ ATPase beta subunit;Gastric hydrogen potassium ATPase;Gastric hydrogen potassium ATPase beta;Hydrogen/potassium exchanging ATPase 4B;OTTHUMP00000178856;Potassium transporting ATPase beta chain;Potassium transporting ATPase subunit beta;Proton pump;Proton pump beta chain;gastric hydrogen-potassium ATPase, beta;potassium-transporting ATPase beta chain;ATPase, H+/K+ tra
Recombinant Proteins
- Mouse
- Human
- Chicken
- Rat
- Mus musculus
- Sus scrofa (Pig)
- Dog
- Oryctolagus cuniculus (Rabbit)
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Yeast
- In Vitro Cell Free System
- E.coli expression system
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
ATP4B involved in several pathways and played different roles in them. We selected most pathways ATP4B participated on our site, such as Oxidative phosphorylation,Collecting duct acid secretion,Gastric acid secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP4B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oxidative phosphorylation | ATP6AP1,ATP6AP1B,UQCRH,UQCR11,UQCRC2B,ATP6V0D2,NDUFA9,ATP6V1B1,ATP5F1,ATP5L |
| Gastric acid secretion | EZR,ACTB,KCNE2,KCNJ10,PLCB1,PLCB3,GAST,PRKCB,MYLK2,KCNJ1 |
| Collecting duct acid secretion | ATP4A,ATP6V1B1,ATP6V1E1,CLCNKB,TCIRG1,ATP6V0A4,ATP6V0C,ATP6V0D1,ATP6V1F,ATP6V1G2 |
Protein Function
ATP4B has several biochemical functions, for example, hydrogen:potassium-exchanging ATPase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP4B itself. We selected most functions ATP4B had, and list some proteins which have the same functions with ATP4B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | C5orf30,ADRB3,TMEM88,CCNT1,NDRG4,TMEM30B,UNC119,RAB35,FEN1,STX2 |
| hydrogen:potassium-exchanging ATPase activity | ATP12A,ATP4A,ATP6V1E1B |
Interacting Protein
ATP4B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP4B here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP4B.
CCNDBP1;BPGM;AGO3
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