Atg7
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Official Full Name
ATG7 autophagy related 7 homolog (S. cerevisiae) -
Overview
This gene was identified based on homology to Pichia pastoris GSA7 and Saccharomyces cerevisiae APG7. In the yeast, the protein appears to be required for fusion of peroxisomal and vacuolar membranes. The protein shows homology to the ATP-binding and catalytic sites of the E1 ubiquitin activating enzymes. -
Synonyms
ATG7;ATG7 autophagy related 7 homolog (S. cerevisiae);GSA7;APG7L;APG7-LIKE;DKFZp434N0735;APG7 autophagy 7-like (S. cerevisiae);Ubiquitin-like modifier-activating enzyme ATG7;ATG12-activating enzyme E1 ATG7;Autophagy-related protein 7;hAGP7;Ubiquitin-activating enzyme E1-like protein;OTTHUMP00000160157;OTTHUMP00000207591;OTTHUMP00000207592;ubiquitin activating enzyme E1-like protein
Recombinant Proteins
- Mouse
- Human
- Chicken
- Rhesus macaque
- Rat
- E.coli
- Sf21 Cells
- Insect Cells
- Wheat Germ
- HEK293
- Mammalian Cells
- In Vitro Cell Free System
- His
- GST
- DDK
- Myc
- Non
- Avi
- Fc
- Flag
Involved Pathway
Atg7 involved in several pathways and played different roles in them. We selected most pathways Atg7 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with Atg7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Class I MHC mediated antigen processing & | DZIP3,FBXO3,LRRC41,TRIM50,UBR2,RNF25,UBE2F,ASB6,ASB3,TRIM69 |
| Immune System | CD200R1,GBP4,STUB1,CASPBL,LILRB2,BTR16,SIRPB1,ASB14,RAP1GAP2B,DYNLL2 |
| presentation | DZIP3,ASB4,CTSS,TRIM41,VPRBP,UBE2F,KLHL21,UBE2V2,UBE2J2,HUWE1 |
| Senescence and Autophagy | SLC39A1,AMBRA1,IGFBP7,COL10A1,SLC39A2,SLC39A3,MAP1LC3C,FKBP8,LC3,IGFBP5 |
| Cellular responses to stress | HIST4H4,ATG4A,AGO3,TERF2,GABARAP,ACD,EHMT2,CHMP4B,ERF,CDKN2C |
| Regulation of autophagy | PRKAA1,ATG4A,PIK3C3,IFNA17,IFNA7,IFNA5,GABARAP,BECN1,IFNPHI1,GABARAPL1 |
| Macroautophagy | MAP1LC3C,DYNLL2B,GABARAPL2,WIPI2,MAP1LC3B,LC3,AMBRA1A,RB1CC1,DYNLL2A,WDR45 |
| Antigen processing: Ubiquitination & | RNF25,ASB14,TRIM69,UBE2V1,ASB6,VPRBP,ASB2,RNF220,ASB10,ASB3 |
| Proteasome degradation | RNF14,UCHL3,FBXO17,RNF138,UBE2V1,PJA1,RNF123,SPSB2,SPSB1,HUWE1 |
Protein Function
Atg7 has several biochemical functions, for example, Atg12 activating enzyme activity,Atg8 activating enzyme activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Atg7 itself. We selected most functions Atg7 had, and list some proteins which have the same functions with Atg7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor binding | TAF12,MECP2,PITX2,NKX3,NBN,TRP53,AIP,MAPK1,UBN1,DIP2B |
| protein binding | OPRL1,ADRA2B,ACTR6,MAP2K7,PPAP2B,PROX1,BASP1,EPN2,C22orf23,RBMY1A1 |
| protein homodimerization activity | CHMP3,LGALS1,ADAM10,SIAH1A,CCBL2,JAM3,LCN2,ATPIF1,WWTR1,BCL2A1 |
| ubiquitin activating enzyme activity | UBA7,UBE1Y1,UBA6,UBA1,SAE1 |
Interacting Protein
Atg7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Atg7 here. Most of them are supplied by our site. Hope this information will be useful for your research of Atg7.
MAP1LC3B;GABARAP;GABARAPL2
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References
- Okada, M; Oikawa, M; et al. Immunohistochemical assessment of ATG7, LC3, and p62 in ameloblastomas. JOURNAL OF ORAL PATHOLOGY & MEDICINE 43:606-612(2014).
- Chen, M; Hong, MJ; et al. Essential role for autophagy in the maintenance of immunological memory against influenza infection. NATURE MEDICINE 20:507-514(2014).
