ASNA1
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Official Full Name
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) -
Overview
This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion. -
Synonyms
ASNA1;arsA arsenite transporter, ATP-binding, homolog 1 (bacterial);arsA (bacterial) arsenite transporter, ATP binding, homolog 1;ATPase ASNA1;ARSA I;GET3;golgi to ER traffic 3 homolog (S. cerevisiae);transmembrane domain recognition complex;40kDa
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- In Vitro Cell Free System
- HEK293
- His
- GST
- Non
- His&SUMO
- Myc&DDK
- His&Fc&Avi
Involved Pathway
ASNA1 involved in several pathways and played different roles in them. We selected most pathways ASNA1 participated on our site, such as IRE1alpha activates chaperones,Metabolism of proteins,Unfolded Protein Response (UPR), which may be useful for your reference. Also, other proteins which involved in the same pathway with ASNA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| IRE1alpha activates chaperones | KLHDC3,PDIA6,HYOU1,YIF1A,WIPI1,CXXC1,FKBP14,DNAJB9,SEC63,DDX11 |
| Metabolism of proteins | ADAMTS10,TRAPPC4,EIF4H,GCNT3,GALNT5,GALNTL2,SPON1B,GALNTL5,SUMF2,ADAMTS5 |
| Unfolded Protein Response (UPR) | HDGF,SERP1,KLHDC3,SEC63,WIPI1,CTDSP2,TPP1,HYOU1,FKBP14,YY2 |
| XBP1(S) activates chaperone genes | CXXC1,YIF1A,CTDSP2,DDX11,FKBP14,TPP1,DNAJB9,KDELR3,HDGF,SEC63 |
Protein Function
ASNA1 has several biochemical functions, for example, ATP binding,ATPase activity,arsenite transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ASNA1 itself. We selected most functions ASNA1 had, and list some proteins which have the same functions with ASNA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATPase activity | KIF3C,ATP13A3,ABCB6,KIF14,ABCC1,ABCC8,KIF7,Abca2,KIF4,ATAD2 |
| metal ion binding | NRAP,IRF2BP2A,ZBED2,MYLK,AMDHD2,CYBRD1,RPE65,PRSS1,F13A1,CCDC71L |
| ATP binding | MB21D1,TP53,IP6K1,ACTR1A,RAF1B,CLK4B,EPHA10,TLK2,PAPSS2B,IRAK1 |
| arsenite transmembrane transporter activity | AQP10A,AQP9A,AQP3A,AQP9B,AQP3B |
| transporter activity | ATP6V0B,CLVS1,ATP5O,SLCO4C1,LCN12,SLC23A2,TTPAL,NUP98,FABP11A,PACSIN2 |
| protein binding | SRSF11,POT1A,FBN1,RSG1,LPXN,TBC1D17,THRA,COMMD3,ZNF276,PXN |
Interacting Protein
ASNA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASNA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASNA1.
ASPH;GPX7;HILPDA;UBL4A;CACNA1A;PFDN1;TTR;TK1;GET4;q81jv5_bacan;metG1;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate
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