ARSB
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Official Full Name
arylsulfatase B -
Overview
Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targetted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. -
Synonyms
ARSB;arylsulfatase B;ARSB_HUMAN;ArylsulfataseB;ASB;G4S;MPS6;N acetylgalactosamine 4 sulfatase;N-acetylgalactosamine-4-sulfatase;OTTHUMP00000135268;OTTHUMP00000222674
Recombinant Proteins
- Human
- Bacillus subtilis
- Staphylococcus
- Mouse
- Rat
- CHO
- E. coli or Yeast
- Mammalian Cell
- Wheat Germ
- E.Coli or Yeast
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian cells
- HEK293T
- Yeast
- His
- Non
- GST
- Flag
- Myc&DDK
- His&SUMO
- His&Fc&Avi
Involved Pathway
ARSB involved in several pathways and played different roles in them. We selected most pathways ARSB participated on our site, such as Glycosaminoglycan degradation,Metabolic pathways,Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARSB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycosaminoglycan degradation | HYAL1,GNS,HYAL6,GNSB,HYAL3,IDS,HPSE,HYAL2,SGSH,SPAM1 |
| Metabolic pathways | POLR3C,POLR3GL,DAK,NAGLU,NDUFA1,GBA,PNPLA2,ADPGK,PLCD3A,NDST4 |
| Lysosome | CTSW,CTSSA,GALNS,SUMF1,AP1M1,NAPSA,PLA2G15,CTSSB.2,CD68,CTSK |
Protein Function
ARSB has several biochemical functions, for example, N-acetylgalactosamine-4-sulfatase activity,arylsulfatase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARSB itself. We selected most functions ARSB had, and list some proteins which have the same functions with ARSB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| N-acetylgalactosamine-4-sulfatase activity | GALNS |
| metal ion binding | SIRT4,RBM4.2,TRIT1,ATP2B3A,ADI1,ZC3H3,ABLIM1B,B3GAT1,ZDHHC13,POLL |
| arylsulfatase activity | ARSD,ARSG,ARSK,ARSE,ARSA,SULF2,ARSI,ARSJ,ARSH,SULF1 |
Interacting Protein
ARSB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARSB here. Most of them are supplied by our site. Hope this information will be useful for your research of ARSB.
MYC;ESR1
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References
- Bhattacharyya, S; Feferman, L; et al. Regulation of chondroitin-4-sulfotransferase (CHST11) expression by opposing effects of arylsulfatase B on BMP4 and Wnt9A. BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 1849:342-352(2015).
- Ferla, R; Claudiani, P; et al. Prevalence of Anti-Adeno-Associated Virus Serotype 8 Neutralizing Antibodies and Arylsulfatase B Cross-Reactive Immunologic Material in Mucopolysaccharidosis VI Patient Candidates for a Gene Therapy Trial. HUMAN GENE THERAPY 26:145-152(2015).
