AR
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Official Full Name
androgen receptor -
Overview
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] -
Synonyms
AR;androgen receptor;KD;AIS;TFM;DHTR;SBMA;HYSP1;NR3C4;SMAX1;HUMARA;dihydrotestosterone receptor;androgen nuclear receptor variant 2;nuclear receptor subfamily 3 group C member 4
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- Rhesus macaque
- Zebrafish
- Silk moth
- Insect Cells
- E.coli
- Sf9 Cells
- Mammalian Cells
- E.Coli/Yeast
- Wheat Germ
- Sf21 Cells
- HEK293
- His
- Flag
- His&Myc&SUMO
- His&Strep&SUMO
- GST
- GST&His
- Non
- Avi&Fc&His
- Flag&His
Involved Pathway
AR involved in several pathways and played different roles in them. We selected most pathways AR participated on our site, such as Oocyte meiosis,Pathways in cancer,Prostate cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with AR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Prostate Cancer | LEF1,BRAF,TRP53,MAPK1,ERBB2,SOS1,PIK3CG,CPN1,PDGFD,RELA |
| Pathways in cancer | LEF1,GNAQ,FLT3LG,WNT16,WNT3A,PDGFRA,TGFBR1,MAP2K2,TGFA,FGFR2 |
| Oocyte meiosis | PPP3CB,SMC3,RPS6KA6,FBXW11,PRKACBB,MAP2K1,YWHAG,CUL1B,CALM1,CPEB1 |
Protein Function
AR has several biochemical functions, for example, ATPase binding,DNA binding,POU domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AR itself. We selected most functions AR had, and list some proteins which have the same functions with AR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | NFKB2,MCM5,PRKCB,NR5A1A,DHX30,HIST2H3C1,FOXN4,CBX5,SHMT2,SOX9 |
| androgen receptor binding | TGFB1I1,KAT5,CDK7,DDX5,SMARCA4,PARK7,WIPI1,RNF6,KDM3A,NRIP1 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | PLSCR1,ATF2,ARNT2,WT1,GLIS2,TCF21,ZIC3,POU4F1,RFX4,FOXC2 |
| lipid binding | BPIFB7,RUFY1,STARD8,ATP5G1,FAM123C,FABP1B.1,PACSIN1B,ACOT12,PLEKHA2,FNBP1 |
| metal ion binding | TNKS2,ZNF396,PVALB7,KITA,ATP1A3,ZNF512,ARMC1L,MGAT1,ELP3,ZNF480 |
| androgen receptor activity | NR1I3,NKX3,NKX3-1 |
| protein domain specific binding | NR0B1,DBNL,BASP1,PTPN11,SCN5A,PPP3R1,ITGA3,ESRRA,SHROOM2,NEFL |
| receptor binding | TNFSF18,TNFSF13B,AGXT,FGF20B,PVRL1,CXCL12,AKAP9,FGF11A,NRG4,CD160 |
| androgen binding | TSPO,ALDH1A1,SHBG |
Interacting Protein
AR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AR here. Most of them are supplied by our site. Hope this information will be useful for your research of AR.
Resources
Research Area
Cancer Drug TargetsTranscription Regulators in VSMC
Cancer Stem Cell Transcription Factors
Related Services
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References
- Wang, YY; Tang, L; et al. Multiplexed gold nanorod array biochip for multi-sample analysis. BIOSENSORS & BIOELECTRONICS 67:18-24(2015).
- Tilli, TM; Ferreira, LB; et al. Osteopontin-c mediates the upregulation of androgen responsive genes in LNCaP cells through PI3K/Akt and androgen receptor signaling. ONCOLOGY LETTERS 9:1845-1850(2015).
