APLN
-
Official Full Name
apelin -
Overview
This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1. -
Synonyms
APLN;apelin;apelin, AGTRL1 ligand;XNPEP2;AGTRL1 ligand;APEL;APEL_HUMAN;Apelin-13;APJ endogenous ligand
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Zebrafish
- Mouse
- HEK293
- Wheat Germ
- E.coli
- Mammalian Cells
- In Vitro Cell Free System
- C-hFc-Avi
- Fc
- GST
- His
- S
- MBP
- Non
- Avi
- mFc
Involved Pathway
APLN involved in several pathways and played different roles in them. We selected most pathways APLN participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (i) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with APLN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Peptide ligand-binding receptors | CXCL11.8,EDN2,QRFPR,GPR37B,CCL19A.2,NMBA,NMBB,CXCR7B,PNOC,EDNRAB |
| Class A/1 (Rhodopsin-like receptors) | PENK,GPR31B,PNOC,ADRA1B,NMU,OPN4.1,CXCR6,NPFFR2,DRD5,PPY |
| GPCR ligand binding | PNOC,EMR3,RLN2,NMUR1,OPN1LW2,OPN1LW1,HRH3,GPR132,TAC2,NPSR1 |
| G alpha (i) signalling events | RGS14,HRH3,LPAR2B,PTGDR2,OXER1,S1PR3,ANXA1,OXGR1,AGT,SSTR3 |
| Signal Transduction | TAAR1,NEDD8L,PROKR2,CD97,EDNRAB,RLBP1B,DRAP1,CCK,ZNRF3,DHRS9 |
| GPCR downstream signaling | RHOL,OPN4,NPS,CRHR2,CRH,INSL3,FFAR3,PROK2,CRHB,SCT |
| Signaling by GPCR | TAS2R16,ARHGAP4A,ADCYAP1B,INSL3,VIP,XK,OR4D2,UTS2,MLN,HEBP1 |
Protein Function
APLN has several biochemical functions, for example, G-protein coupled receptor binding,apelin receptor binding,hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APLN itself. We selected most functions APLN had, and list some proteins which have the same functions with APLN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | PVRL3B,FGF12B,SMARCD1,PTK2,HFE,APOF,PLAUR,ZAP70,PVRL3,INSL3 |
| G-protein coupled receptor binding | HSPA1B,STUB1,RSPO3,SAA1,USP33,NMS,PARK2,GNA13A,GNA11A,CORT |
| hormone activity | IGF2B,SST3,GPHA2,GCG,INHBC,UTS2,RLN3A,PRL7A1,METRNL,SMTLA |
Interacting Protein
APLN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APLN here. Most of them are supplied by our site. Hope this information will be useful for your research of APLN.
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