API5
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Official Full Name
apoptosis inhibitor 5 -
Overview
This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
API5;apoptosis inhibitor 5;AAC 11;AAC11;API5 like 1;API5L1;fibroblast growth factor 2 interacting factor 2;migration inducing protein MIG8;FIF;antiapoptosis clone 11 protein;migration-inducing protein MIG8;cell migration-inducing gene 8 protein
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rhesus macaque
- Zebrafish
- E.coli
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- HEK293
- HEK293T
- His
- GST
- His&Fc&Avi
- Myc&DDK
- N-His&C-Myc
Involved Pathway
API5 involved in several pathways and played different roles in them. We selected most pathways API5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with API5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
API5 has several biochemical functions, for example, fibroblast growth factor binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by API5 itself. We selected most functions API5 had, and list some proteins which have the same functions with API5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| fibroblast growth factor binding | FGFR1A,FIBPA,TGFBR3,CXCL13,S100A13,CEP57,RPS2,FIBPB,GLG1B,PTPRZ1 |
| poly(A) RNA binding | ZFP579,RRP9,FXR2,MRPS15,KIAA0020,SCG3,ZFP598,SYNE1,U2SURP,RBM47 |
Interacting Protein
API5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with API5 here. Most of them are supplied by our site. Hope this information will be useful for your research of API5.
Resources
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References
- Accialini, P; Hernandez, SF; et al. A link between Notch and progesterone maintains the functionality of the rat corpus luteum. REPRODUCTION 149:1-10(2015).
- Xiao, ZG; Sperl, B; et al. Metformin and salinomycin as the best combination for the eradication of NSCLC monolayer cells and their alveospheres (cancer stem cells) irrespective of EGFR, KRAS, EML4/ALK and LKB1 status. ONCOTARGET 5:12877-12890(2014).
