APEX1
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Official Full Name
APEX nuclease (multifunctional DNA repair enzyme) 1 -
Overview
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. -
Synonyms
APEX1;APEX nuclease (multifunctional DNA repair enzyme) 1;APE;APX;APE1;APEN;APEX;HAP1;REF1
Recombinant Proteins
- Zebrafish
- Human
- Mouse
- Rat
- Rhesus macaque
- Chicken
- Mammalian Cell
- E.coli
- Wheat Germ
- HEK293
- Yeast
- In Vitro Cell Free System
- Mammalian cells
- HEK293T
- His
- Non
- HIS
- T7
- GST
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
APEX1 involved in several pathways and played different roles in them. We selected most pathways APEX1 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with APEX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Base excision repair | HMGB1,UNGA,NEIL3,MBD4,PNKP,PARP2,PCNA,PARP4,NEIL1,XRCC1 |
Protein Function
APEX1 has several biochemical functions, for example, 3-5 exonuclease activity,DNA binding,DNA-(apurinic or apyrimidinic site) lyase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by APEX1 itself. We selected most functions APEX1 had, and list some proteins which have the same functions with APEX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphodiesterase I activity | FAN1,ENPP2,ENPP1 |
| uracil DNA N-glycosylase activity | UNG,UNGA,SMUG1,TDG,CCNO,TDG.1 |
| double-stranded DNA 3-5 exodeoxyribonuclease activity | APEX2 |
| DNA-(apurinic or apyrimidinic site) lyase activity | HMGA2,HMGA1A,NEIL3,ALKBH1,NEIL1,HMGA1-RS1,HMGA1,RPS3,NEIL2,APEX2 |
| damaged DNA binding | NEIL2,FEN1,ERCC3,RUVBL2,ERCC4,RPA2,XRCC1,RAD1,POLB,RAD52 |
| site-specific endodeoxyribonuclease activity, specific for altered base | DNA2 |
| DNA binding | HIST1H2BH,PIF1,ZNF319,GON4L,ZNF563,BBX,ISL2B,TCF15,TFDP1,BHLHE22 |
| RNA-DNA hybrid ribonuclease activity | RNASEH2A,RNASEH1,EXO1,RNASEH2B,FEN1,RNASEH2C |
| poly(A) RNA binding | NARG1,UBE2O,ETF1B,DKC1,RPS19BP1,NONO,RPS26,LUC7L2,STIP1,SFRS9 |
Interacting Protein
APEX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APEX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of APEX1.
EP300;HSPA1A;SIRT1;mdm2_human_probe;SRPK2
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