APCS
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Official Full Name
amyloid P component, serum -
Overview
The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. -
Synonyms
APCS;amyloid P component, serum;SAP;PTX2;MGC88159;serum amyloid P-component;pentaxin-related;OTTHUMP00000024355;9.5S alpha-1-glycoprotein
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Wheat Germ
- Human Cell
- HEK293T
- Mammalian cells
- Mouse Serum
- Human Serum
- GST
- His
- T7
- Non
- Myc&DDK
- His&Fc&Avi
- Fc
- Flag
Involved Pathway
APCS involved in several pathways and played different roles in them. We selected most pathways APCS participated on our site, such as Amyloid formation,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with APCS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Amyloid formation | HIST3H2BB,CST3,HIST2H3C,CEACAM21,TGFBI,LTF,SAA1,NAT8B,HIST4H4,TTR |
| Metabolism of proteins | CEACAM21,PROCA,NSFB,ADAMTSL4,GPR119,SPON1B,TIMM9,COX17,PMPCB,SEC23IP |
Protein Function
APCS has several biochemical functions, for example, calcium ion binding,carbohydrate binding,complement component C1q binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APCS itself. We selected most functions APCS had, and list some proteins which have the same functions with APCS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| virion binding | CLEC4M,HSP90B1,PTX3,CD209,TSG101,PVRL1,HIPK2,PPIA |
| complement component C1q binding | CRP,C4A,C1QBP,CD93,CALR,PTX3 |
| carbohydrate binding | LGALS9C,PKD1,LGALS2A,CLEC12A,CLEC2H,SIGLEC7,ATRN,Cd209g,CDIPT,FCN1 |
| unfolded protein binding | DNAJB1,CCT3,CCT4,HSPA2,SIL1,UGGT1,GRPEL2,HSPA8,HSPA1L,DNAJA1 |
| calcium ion binding | PCDHGA1,FKBP14,SDF4,GRIN1,PLA2G1B,OCM,CAPRIN1A,THBS3,CABP1A,SRI |
Interacting Protein
APCS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APCS here. Most of them are supplied by our site. Hope this information will be useful for your research of APCS.
GOT2;GK;GRB2;HES1;COPS5;d-mannose
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References
- Veninga, H; Borg, EGF; et al. Antigen targeting reveals splenic CD169(+) macrophages as promoters of germinal center B-cell responses. EUROPEAN JOURNAL OF IMMUNOLOGY 45:747-757(2015).
- Zhang, Y; Hu, XY; et al. Anti-CD40-induced inflammatory E-cadherin plus dendritic cells enhance T cell responses and antitumour immunity in murine Lewis lung carcinoma. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 34:-(2015).
