AP2M1
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Official Full Name
adaptor-related protein complex 2, mu 1 subunit -
Overview
This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
AP2M1;adaptor-related protein complex 2, mu 1 subunit;CLAPM1;AP-2 complex subunit mu;AP 2 mu 2 chain;AP50;clathrin adaptor complex AP2;mu subunit;clathrin assembly protein complex 2 medium chain;clathrin coat adaptor protein AP50;clathrin associ
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Rhesus macaque
- Chicken
- Rat
- E.coli
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- Yeast
- Mammalian cells
- HEK293T
- GST
- His
- T7
- Non
- Flag
- His&Fc&Avi
- His&SUMO
- Myc&DDK
Involved Pathway
AP2M1 involved in several pathways and played different roles in them. We selected most pathways AP2M1 participated on our site, such as Adaptive Immune System,Arf1 pathway,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP2M1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | NTN1B,FGFR1B,DAB2IPB,SEMA6D,DPYSL5A,CSF2RB,DPYSL5,PLXNA3,MARK3,KALRNB |
| Developmental Biology | POU5F3,FGF8B,ARPC5,TCF3B,KALRN,SPRED2,RASGEF1A,MED21,ARHGEF28,RASGRP1 |
| Beta-catenin independent WNT signaling | AP2A2,CLTB,DVL3,DVL2,PRICKLE1,AGO1,AGO3,MOV10,ROR1,GNB5 |
| Arf1 pathway | CLTB,USO1,AP2A1,ARFIP2,CLTA,ARF1 |
| EPH-Ephrin signaling | AP2S1,MYL12B,SHB,EFNB3,ARPC2,EFNB2A,AP2A2,ARPC4,EFNA1A,EFNA5 |
| EGFR downregulation | AP2A2,AP2A1,AP2S1,SPRY2,AP2B1,STAM2,PTPRK,SPRY1 |
| Adaptive Immune System | SIGLEC7,DYNC1H1,LAIR1,CD200,TRIM9,VPRBP,GAN,SPSB4,CMTM2A,UBA5 |
| Disease | RPL35,ACAN,NPM1,VPS37A,AP2A1,MYO18A,RBP4,OPN1MW2,LRRFIP1,STX1B |
Protein Function
AP2M1 has several biochemical functions, for example, contributes_to clathrin adaptor activity,ion channel binding,lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AP2M1 itself. We selected most functions AP2M1 had, and list some proteins which have the same functions with AP2M1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to clathrin adaptor activity | AP2B1,AP2A1,AP2A2,AP2S1 |
| low-density lipoprotein particle receptor binding | CCDC167,APOEA,SYT1,APOA5,ARRB2,SACS,MMP13,SNX17,APOE,MESDC2 |
| signal sequence binding | SRP68,AP2B1 |
| transporter activity | PTGDSB,AQP8A.1,RBP7,ATP6V0B,AP2S1,LCN2,ABCB10,APODA.1,ATP5G1,AP3D1 |
| lipid binding | STARD8,ANXA6,FAM123A,CRABP1B,PPARA,OSBPL9,ACBD7,BPIFB6,PTGS2,MAL |
| ion channel binding | PACS1,CHERP,FXYD1,ACTN2,KCNQ3,ABCC9,ANK2,CIB1,ACTN4,CALM2 |
| protein binding | MYEF2,FCRL2,CRYBA4,TBX2A,N6AMT1,CBX5,DCTN2,BEGAIN,FBXL5,CMTM3 |
Interacting Protein
AP2M1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP2M1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP2M1.
TBC1D5;AAK1;RALBP1;EGFR;AP2B1;p27958-pro_0000037566;AP2A2
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References
- Huang, X; Dai, FF; et al. The Identification of Novel Proteins That Interact With the GLP-1 Receptor and Restrain its Activity. MOLECULAR ENDOCRINOLOGY 27:1550-1563(2013).
- Dadlchah, E; Naseh, H; et al. A Cancer-Array Approach Elucidates the Immune Escape Mechanism and Defects in the DNA Repair System in Esophageal Squamous Cell Carcinoma. ARCHIVES OF IRANIAN MEDICINE 16:463-470(2013).
