ANGPTL4
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Official Full Name
ANGPTL4 angiopoietin-like 4 -
Overview
Angiopoietin-like protein 4 (ANGPTL4), also known as PPARγ angiopoietinrelated protein, fastinginduced adipose factor, or hepatic fibrinogen /angiopoietin-related protein (HFARP), is a secreted adipokine predominantly expressed in adipose tissue and liver. The experimental results show that ANGPTL4 is a blood-borne hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. Serum levels of ANGPTL4 were decreased in patients with type 2 diabetes. In animal experiments, ANGPTL4 treatments might reduce hyperglycemia, and improve glucose tolerance by decreasing hepatic glucose production and enhancing insulin-mediated inhibition of gluconeogenesis. However, the molecular mechanisms underlying its metabolic actions remain elusive. -
Synonyms
ANGPTL4;angiopoietin-like 4;angiopoietin-related protein 4;angiopoietin related protein 4;ARP4;fasting induced adipose factor;FIAF;hepatic angiopoietin related protein;hepatic fibrinogen/angiopoietin related protein;HFARP;NL2;peroxisome proliferator activated receptor (PPAR) gamma induced angiopoietin related protein;PGAR;pp1158;PPARG angiopoietin related protein;angiopoietin-like protein 4;fasting-induced adipose factor;hepatic angiopoietin-related protein;hepatic fibrinogen/angiopoietin-related protein;peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin-related protein;ANGPTL2
Recombinant Proteins
- Human
- Cynomolgus
- Rat
- Mouse
- Cattle
- Pig
- Zebrafish
- Macaca Fascicularis
- HEK293
- E.coli
- COS-7 cells
- Mammalian cells
- CHO
- N-His
- Wheat Germ
- Human Cell
- Mammalian Cell
- In Vitro Cell Free System
- His
- Flag
- FLAG
- Fc
- GST
- Non
- His&Flag
- His&GST
- His&T7
- His&Fc&Avi
Involved Pathway
ANGPTL4 involved in several pathways and played different roles in them. We selected most pathways ANGPTL4 participated on our site, such as PPAR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANGPTL4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PPAR signaling pathway | SCDB,PCK2,ACSL3A,ACSL4B,SCD5,ACOX1,FABP1A,RXRG,RXRBA,CYP27A1 |
Protein Function
ANGPTL4 has several biochemical functions, for example, enzyme inhibitor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANGPTL4 itself. We selected most functions ANGPTL4 had, and list some proteins which have the same functions with ANGPTL4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme inhibitor activity | OAZ2B,TAE1,PPP1R12A,OAZ2A,CD46,ANGPTL3,ATPIF1,SCG5,UGT1A9,UGT1A1 |
| protein binding | SLC14A2,MTPAP,ARL6IP4,ZNF207,STXBP4,RXRA,VSTM2L,PMEPA1,CSNK1D,SLC35F6 |
Interacting Protein
ANGPTL4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANGPTL4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANGPTL4.
ITGB5;ITGB1;AURKA;TGFB1;ESR1;FGFR4;CDKN2A;CDKN2C;CASP8;FBXW7;BRMS1;RAC1;PTK2
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