ANG
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Official Full Name
Angiogenin -
Overview
Angiogenin (Ang) also known as ribonuclease 5 is a protein that in humans is encoded by the ANG gene. Angiogenin is a potent stimulator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. Hooper et al. (2003) reviewed the evidence that angiogenins are involved in host defense and noted that inflammation provokes upregulated ANG mRNA expression in liver and an increase in detectable ANG protein in serum. Weremowicz et al. (1989, 1990) assigned the human angiogenin gene to chromosome 14q11. -
Synonyms
Angiogenin;Ang;ribonuclease 5
Recombinant Proteins
- Human
- Mouse
- Cattle
- Pig
- Rat
- Chicken
- E.coli
- Mammalian Cells
- E.Coli/Yeast
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- Non
- GST&His
- His&T7
- GST
- DDK&Myc
- Avi&Fc&His
Involved Pathway
ANG involved in several pathways and played different roles in them. We selected most pathways ANG participated on our site, such as Adherens junctions interactions,Cell junction organization,Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell-Cell communication | CDH3,CDH2,JUP,FBLIM1,SIRPB1,COL17A1A,CLDN16,KIRREL3L,CDH18A,CDH6 |
| Adherens junctions interactions | CDH17,CDH11,CTNND1,JUP,CDH7,PVRL1A,CDH24,CDH5,CDH18A,CADM2 |
| Cell-cell junction organization | CDH6,CDH7,CTNND1,CLDN23,CDH18A,CDH10A,CDH12,CDH13,JUPA,CADM2 |
| Cell junction organization | CLDN16,CD151,CADM2A,CDH5,JUPA,CLDN3,COL17A1A,CDH12A,ITGB1B.1,FBLIM1 |
Protein Function
ANG has several biochemical functions, for example, DNA binding,actin binding,copper ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANG itself. We selected most functions ANG had, and list some proteins which have the same functions with ANG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endonuclease activity | PMS2,RNASEKB,SMG6,NTHL1,RNASE4,RNASE7,EAR1,CENPT,CL2,EAR14 |
| ribonuclease activity | RNASEL4,RNASE4,EAR2,RNASEH2A,EAR3,RNASE3,EAR5,RNASET2,EAR14,RNASE7 |
| receptor binding | DRD1A,HCST,PTK2AA,HLA-G,MBL2,PVRL2,EPB49,NXPH3,FYNB,MAP7 |
| actin binding | NF2B,CCDC88A,DMD,DBNLB,FMNL2,CNN2,HDAC6,HPCA,XIRP2,SPTBN2 |
| DNA binding | YY1,NFE2L1B,KDM1B,STAT2,PCGF2,MIER3,HOXA2B,JUNB,SETDB1A,SUPT3H |
| peptide binding | PPIB,ADNP,OXTRL,NPFFR1L2,GNRHR,NPFFR1,HCRTR1,FNTB,CMA1,ANPEP |
| protein homodimerization activity | RNF17,ENO3,SMAD2,CUBN,CIDEA,RCHY1,TYR,RAB11FIP4,UBE4A,SNX6 |
| heparin binding | VTN,FMODA,NRP2,PRG2,LAMC2,SLIT1,APOA5,C6orf25,PLA2G2D,CTGF |
| rRNA binding | DDX21,MRPS7,RPL23A,RPL11,RPS11,NOL12,EMG1,RPS4X,RPL12,MTERFD2 |
Interacting Protein
ANG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANG here. Most of them are supplied by our site. Hope this information will be useful for your research of ANG.
ACTN2;FST;RNH1;TDGF1;FST;PTEN;ATP6AP1;ABCG8
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References
- Berger, JM; Vaillant, N; et al. PCSK9-deficiency does not alter blood pressure and sodium balance in mouse models of hypertension. ATHEROSCLEROSIS 239:252-259(2015).
- Glenn, DJ; Cardema, MC; et al. Cardiac steatosis potentiates angiotensin II effects in the heart. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 308:H339-H350(2015).
