ALDOA
-
Official Full Name
aldolase A, fructose-bisphosphate -
Overview
The protein encoded by this gene, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10. -
Synonyms
ALDOA;aldolase A, fructose-bisphosphate;fructose-bisphosphate aldolase A;ALDA;Aldolase A fructose bisphosphatase;OTTHUMP00000162983;OTTHUMP00000162984;muscle-type aldolase;lung cancer antigen NY-LU-1;fructose-1,6-bisphosphate triosephosphate-lyase;GSD12
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- Insect Cells
- His
- GST
- T7
- Non
- Flag
- Avi
- Fc
- DDK
- Myc
Involved Pathway
ALDOA involved in several pathways and played different roles in them. We selected most pathways ALDOA participated on our site, such as Glycolysis / Gluconeogenesis,Pentose phosphate pathway,Fructose and mannose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDOA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Biosynthesis of amino acids | THA1,PFKMB,GOT1,TALDO1,GOT2,BCAT1,ACO2,OTC,GOT2B,IDH3B |
| Glycolysis / Gluconeogenesis | HKDC1,LDHAL6A,HK2,PKM2,HK3,pykF,PGAM1A,ALDH1A3,PFKMA,ADH2-1 |
| Pentose phosphate pathway | RBKS,PFKMB,RGN,PGD,ALDOAB,G6PD,ALDOC,RPE,TKTL2,GPIB |
| HIF- signaling pathway | HMOX1,NOS2,NFKB1,PIK3R2,GAPDH,INS,TF,TFRC,IL6,PLCG1 |
| Fructose and mannose metabolism | FBP1A,AKR1B1L,PFKFB4L,AKR1B8,FBP2,AKR1B10,GMPPAA,PMM2,TSTA3,ENOSF1 |
| Metabolic pathways | TCIRG1,LIPCA,COX4I1,ADSSL,EHHADH,MAPK1IP1L,RDH10,SAT2B,PNMT,GLULC |
| Carbon metabolism | DLST,PGLS,EHHADH,SDHC,GPI1,ALDOAA,ALDH6A1,GM5506,ENO3,MDH2 |
Protein Function
ALDOA has several biochemical functions, for example, actin binding,cytoskeletal protein binding,fructose binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDOA itself. We selected most functions ALDOA had, and list some proteins which have the same functions with ALDOA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytoskeletal protein binding | EZRB,FRMD5,TOR1A,PACSIN1,NEBL,TNNT2A,EPB41L4B,FRMD3,ACTN2,MSNB |
| fructose-bisphosphate aldolase activity | ALDOAA,ALDOC,ALDOB,ALDOCB,ALDOAB,ALDOCA |
| actin binding | MYOT,LIMCH1A,ABLIM1B,TPM4,EZRB,PAWR,MYO19,MYH4,WASH,KLHL2 |
| identical protein binding | GM5077,DAPK1,LCP1,SCUBE1,MID1,MTSS1,GRB7,BNIP2,FTL,ERBB2 |
| fructose binding | PFKL,ALDOB,PFKM |
| tubulin binding | CDK5RAP2,BRCA1,LRRK2,STMN3,PARK2,MAP1S,DAG1,STMN2A,PRNP,EML2 |
| protein binding | ZNHIT6,CAPRIN2,TOP3A,VHLL,TRAPPC2,CD74,MAP3K9,CD99L2,RHOV,VPS29 |
| poly(A) RNA binding | NONO,CANX,CDC40,RPS9,TRMT6,CPNE3,RBM12B2,RBM27,DARS,POLDIP3 |
Interacting Protein
ALDOA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDOA here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDOA.
PCNA;VCAM1;YWHAZ;OSBPL10;USP15;CACNA1A;BCAT2;EGFR;ALDOB;TFAP2A;ENO1;ENO3;MLH1
Resources
Related Services
Related Products
References
