Alcam
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Official Full Name
activated leukocyte cell adhesion molecule -
Overview
This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. -
Synonyms
ALCAM;activated leukocyte cell adhesion molecule;MEMD;CD166;CD166 antigen;FLJ3851;FLJ38514;MGC71733
Recombinant Proteins
- Human
- Mouse
- Rat
- Cynomolgus
- Rhesus macaque
- Cattle
- Dog
- Rabbit
- Chicken
- Oryctolagus cuniculus (Rabbit)
- HEK293
- Insect Cells
- Mammalian Cells
- C-His
- E.coli
- Human Cells
- Wheat Germ
- In Vitro Cell Free System
- His
- Fc&His
- Fc
- His&T7
- Non
- GST
- Avi&His
- Avi&Fc&His
- His&SUMO
Involved Pathway
Alcam involved in several pathways and played different roles in them. We selected most pathways Alcam participated on our site, such as Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with Alcam were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell adhesion molecules (CAMs) | NLGN4X,ITGB1B.2,CNTNAP2,CD4,SELP,CLDN6,SELE,HLA-DQA2,HLA-DPA1,MPZL1 |
Protein Function
Alcam has several biochemical functions, for example, protein binding,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Alcam itself. We selected most functions Alcam had, and list some proteins which have the same functions with Alcam. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | KIFC3,ARHGAP9,ELMO3,VPS4A,BRPF1,NVL,ARL4D,GAP43,CLDN8,WHSC2 |
| receptor binding | CADM2,GAS6,NOS2,ANGPTL1,Artn,CTNND1,MYO1C,SEMA4D,ICOSLG,VTCN1 |
Interacting Protein
Alcam has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Alcam here. Most of them are supplied by our site. Hope this information will be useful for your research of Alcam.
LGALS1;LGALS3;CD6;ART3;EGFR
Resources
Research Area
Osteoclast MarkersB Cell CD Antigen
Immunoglobulin Superfamily CAMs
Mesenchymal Stem Cell Markers
Intestinal Stem Cell Markers
Osteoblast and Osteoclast Markers
Epithelial Cell Markers and Intracellular Molecules
Neuronal Lineage Markers
Adipose-derived Stem Cell Markers
T Cell Migration
Monocyte Marker CD Antigen
Other Monocytes/Macrophages CD Antigen
CD Antigen (T Cell Migration/Adhesion)
Monocyte Markers
Colon Cancer Stem Cell Markers
Melanoma Cancer Stem Cell Markers
Prostate Cancer Stem Cell Markers
Mesodermal Lineage Markers
Related Services
Related Products
References
- Williams, DW; Anastos, K; et al. JAM-A and ALCAM are therapeutic targets to inhibit diapedesis across the BBB of CD14(+)CD16(+) monocytes in HIV-infected individuals. JOURNAL OF LEUKOCYTE BIOLOGY 97:401-412(2015).
- Ding, V; Chin, A; et al. Generation of novel monoclonal antibodies for the enrichment and characterization of human corneal endothelial cells (hCENC) necessary for the treatment of corneal endothelial blindness. MABS 6:1439-1452(2014).
