AGT
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Official Full Name
angiotensinogen (serpin peptidase inhibitor, clade A, member 8) -
Overview
The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. -
Synonyms
AGT;angiotensinogen (serpin peptidase inhibitor, clade A, member 8);ANHU;SERPINA8
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- Enterobacteria phage T4
- E.coli
- HEK293
- E.Coli or Yeast
- Wheat Germ
- HEK293F
- Mammalian Cell
- Human Cell
- Mammalian cells
- Human Plasma
- HEK293T
- In Vitro Cell Free System
- His
- His&GST
- His&S
- GST
- Myc&DDK
- Non
- His&Fc&Avi
- His&SUMO
- N-His-SUMO&C-Myc
- Flag
Involved Pathway
AGT involved in several pathways and played different roles in them. We selected most pathways AGT participated on our site, such as ACE Inhibitor Pathway,Adipogenesis,Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with AGT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| G alpha (q) signalling events | TAC1,KALRNB,LPAR2A,GPR17,RGS19,ADRA1D,NMUR1,EDN1,OXTRL,ABHD12 |
| ACE Inhibitor Pathway | AGTR2,ATP6AP2,CMA1,AGTR1,ACE,CYP11B2,CTSG |
| Adipogenesis | FRZB,EGR2,BMP1,CTNNB1,MIXL1,GADD45A,DLK1,CFD,RORAA,KCNA3 |
| Class A/1 (Rhodopsin-like receptors) | ADRB3,PNOC,UTS2D,PROK2,KEL,CCR6,RLN3,ADRB2,OXGR1,OPN4 |
| GPCR ligand binding | INSL3,PYYA,CCR1,TAC2,RAMP3,INSL5,CXCL11.8,FZD10,ADM2,TRH |
| GPCR downstream signaling | PTH2,ADRA2C,CRHR2,RHOGA,DRD2,GCGA,OR56A1,RGS21,GPBAR1,EDN2 |
| Fatty acid, triacylglycerol, and ketone body metabolism | MED20,ACOT11B,ACSF2,TIAM2,SLC25A20,CPT1B,PLIN2,ELOVL1A,Agmo,ACOT12 |
| G alpha (i) signalling events | DRD4,OPN1LW,SSTR4,SSTR3,APLN,RGS14,OPN1MW,TAS2R16,NMUR1,RGS21 |
Protein Function
AGT has several biochemical functions, for example, growth factor activity,hormone activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGT itself. We selected most functions AGT had, and list some proteins which have the same functions with AGT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type endopeptidase inhibitor activity | SERPING1,SERPINA3,PEBP1,FURIN,MUG1,PI3,SPINK3,SERPINA3M,SERPINB3,SERPINB5 |
| type 1 angiotensin receptor binding | GNA13B,JAK2,TYK2,ARRB2,GNB1,GNA13A,ARAP1,BDKRB2,GNG3,GNA13 |
| superoxide-generating NADPH oxidase activator activity | NCF4,NOXA1,PDGFB,NOXO1 |
| growth factor activity | IL7,PDGFC,PDGFB,SPAW,NUDT6,CLEC11A,LFT1,HDGFRP3,GDF6B,GDNFA |
| protein binding | CCL28,TMF1,COG5,SMCO3,COIL,MYO1E,KRTAP10-9,YTHDC1,SAMM50,RRM2 |
| sodium channel regulator activity | SCN1BB,PTPN3,FXYD2,CAV3,FXYD7,GPD1L,FGF12,NOS1,SCN1BA,SGK2A |
| hormone activity | SST1.1,POMC,INSB,Retnla,PYY,GPHB5,LHB,FNDC5B,PPY,LEPB |
Interacting Protein
AGT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGT here. Most of them are supplied by our site. Hope this information will be useful for your research of AGT.
Ance;Agtr1;f_hcvh;GRB2;EWSR1;GSDMB
AGT Related Signal Pathway
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References
- Betensky, M; Witmer, C; et al. Immune hemolytic anemia with drug-induced antibodies to carboplatin and vincristine in a pediatric patient with an optic pathway glioma. TRANSFUSION 54:2901-2905(2014).
- Dihazi, H; Dihazi, GH; et al. Secretion of ERP57 is important for extracellular matrix accumulation and progression of renal fibrosis, and is an early sign of disease onset. JOURNAL OF CELL SCIENCE 126:3649-3663(2013).
