AGR2
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Official Full Name
anterior gradient 2 homolog (Xenopus laevis) -
Overview
AGR2 (Anterior Gradient 2), also known as AG2 (hAG2, HAG2 in human), or GOB4, and AGR3 (Anterior Gradient 3), also known as AG3 (hAG3, HAG3 in human), or BCMP11, are secreted cytoplasmic proteins which are involved in metastasis induction and p53 tumour supressor inhibition. They may serve as molecular markers and potential therapeutic targets for hormone-responsive breast tumours; AGR2 was reported also as a marker of other carcinomas. Xenopus homolog of these proteins is associated with anteroposterior fate determination during early development. -
Synonyms
AGR2;anterior gradient 2 homolog (Xenopus laevis);anterior gradient protein 2 homolog;AG2;HAG 2;PDIA17;protein disulfide isomerase family A;member 17;XAG 2;AG-2;HPC8;anterior gradient homolog 2;secreted cement gland homolog;secreted cement gl
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- HEK293
- E.Coli or Yeast
- Wheat Germ
- E. coli
- Mammalian cells
- Insect Cell
- HEK293T
- Yeast
- In Vitro Cell Free System
- GST
- His
- Myc&DDK
- Non
- N-His
- His&Fc&Avi
- His&Myc
- Flag
Involved Pathway
AGR2 involved in several pathways and played different roles in them. We selected most pathways AGR2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AGR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
AGR2 has several biochemical functions, for example, dystroglycan binding,epidermal growth factor receptor binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGR2 itself. We selected most functions AGR2 had, and list some proteins which have the same functions with AGR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| dystroglycan binding | MAP2,DAG1,AGRN,CLASP1,GYLTL1B,VCL,DMD,AGR3 |
| protein binding | ASB3,ZNF263,CBFA2T3,GATA1,PEX1,JAK2,PPIL3,FGA,HMG20B,IK |
| protein homodimerization activity | PITX2,IKZF2,MTERFD3,RNF17,MTPAP,FLT3LG,TREX1,NR4A2,NOS2,KIAA1804 |
| epidermal growth factor receptor binding | SNX1,VAV2,ATXN2,HBEGFB,CBLC,VAV3,HBEGFA,EGF,YES1,GRB2 |
Interacting Protein
AGR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGR2.
POM121;FABP2;KRT31;CATSPER1;NUP62CL;UBQLN1;UBQLN1
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References
- Mizuuchi, Y; Aishima, S; et al. Anterior gradient 2 downregulation in a subset of pancreatic ductal adenocarcinoma is a prognostic factor indicative of epithelial-mesenchymal transition. LABORATORY INVESTIGATION 95:193-206(2015).
- Pentheroudakis, G; Kotoula, V; et al. A study of gene expression markers for predictive significance for bevacizumab benefit in patients with metastatic colon cancer: a translational research study of the Hellenic Cooperative Oncology Group (HeCOG). BMC CANCER 14:-(2014).
