ADRA1A
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Official Full Name
adrenergic, alpha-1A-, receptor -
Overview
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate;mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A,;-1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns;of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four;transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding;properties. -
Synonyms
ADRA1A;adrenergic, alpha-1A-, receptor;alpha-1A adrenergic receptor;ADA1A_HUMAN;Adra1c;ADRA1L1;Adrenergic alpha1A receptor;Adrenergic alpha1C receptor;Adrenergic receptor alpha 1a;Adrenergic receptor alpha 1c;Alpha 1A adrenoreceptor;Alpha 1C adrenergic receptor;Alpha-1A adrenoceptor;Alpha-1A adrenoreceptor;Alpha-1C adrenergic receptor;Alpha-adrenergic receptor 1c;Alpha1A adrenergic receptor;ALPHA1AAR;alpha 1A-adrenoceptor;alpha 1A-adrenoreceptor;adrenergic, alpha 1A, receptor;adrenergic, alpha 1C, receptor
Recombinant Proteins
- Mouse
- Rhesus macaque
- Human
- Rat
- Oryzias latipes
- Dog
- Oryctolagus cuniculus (Rabbit)
- Bovine
- Mus musculus
- Guinea pig
- Mammalian Cell
- E.coli
- E.Coli or Yeast
- Wheat Germ
- HEK293
- E.coli expression system
- His
- Non
- GST
- His&T7
- His&Fc&Avi
Involved Pathway
ADRA1A involved in several pathways and played different roles in them. We selected most pathways ADRA1A participated on our site, such as AMPK signaling,AMPK signaling pathway,Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADRA1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcium Regulation in the Cardiac Cell | GJA8,CASQ2,GJC1,GJB2,KCNJ3,RGS16,GJB6,GNB3B,RGS14,GJA4 |
| Class A/1 (Rhodopsin-like receptors) | INSL3,ADORA2A,OPN4A,GPR55,ADORA1,PENKA,OPN1SW1,PYY,FFAR3,GPR68 |
| Adrenergic signaling in cardiomyocytes | TNNC1B,PRKACB,ATP1A1,CACNA2D2,CACNG7,CACNB4A,ATF4B1,CACNG1A,PRKACG,CALM3B |
| Adrenoceptors | ADRB1,ADRA2B,ADRA2C,ADRA1B,ADRA1D,ADRA2A,ADRB3,ADRB2 |
| Amine ligand-binding receptors | DRD4,ADRB1,ADRA1B,ADRA2A,CHRM2,ADRA2B,ADRB3,CHRM5,CHRM1,ADRA2C |
| Calcium signaling pathway | HTR4,PLCB1,ATP2B2,EGFRA,ATP2A2,ATP2A2B,ADORA2AA,PDE1B,P2RX6,GRPR |
| AMPK signaling | PPARGC1B,CDKN1A,LOC729991,CPT1A,EEF2,CAMKK2,CPT1C,INS-IGF2,ADRA1B,EIF4EBP1 |
| AMPK signaling pathway | Scd2,PRKAB2,AKT3,GYS1,SCD,CAB39L,INSR,CREB3L4,PCK1,ADIPOR2 |
Protein Function
ADRA1A has several biochemical functions, for example, alpha1-adrenergic receptor activity,protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADRA1A itself. We selected most functions ADRA1A had, and list some proteins which have the same functions with ADRA1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| alpha1-adrenergic receptor activity | ADRA1D,ADRA1BB,ADRA1B |
| protein heterodimerization activity | HIST2H2AC,ABCG1,SOX14,CLNS1A,ITGB1B,HIST1H3D,TGFB2,JAM2,NEFH,HIST1H2BH |
Interacting Protein
ADRA1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADRA1A here. Most of them are supplied by our site. Hope this information will be useful for your research of ADRA1A.
BMP1;ABR;FLNC
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