ADIPOR1
-
Official Full Name
adiponectin receptor 1 -
Overview
This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014] -
Synonyms
ADIPOR1;adiponectin receptor 1;CGI45;PAQR1;ACDCR1;CGI-45;TESBP1A;adiponectin receptor protein 1;progestin and adipoQ receptor family member I
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Mouse
- Mus musculus
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- E. coli
- In Vitro Cell Free System
- In vitro E. coli expression system
- HEK293T
- Insect Cell
- Mammalian cells
- E.coli expression system
- GST
- Myc&DDK
- His
- His&MBP
- His&GST
- His&SUMO
- N-His
- His&Flag
- Non
- His&Myc&SUMO
- His&Fc&Avi
- Flag
- His&Myc
Involved Pathway
ADIPOR1 involved in several pathways and played different roles in them. We selected most pathways ADIPOR1 participated on our site, such as AMPK signaling pathway,Adipocytokine signaling pathway,Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with ADIPOR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Non-alcoholic fatty liver disease (NAFLD) | INS2,FASLG,NDUFC2-KCTD14,NDUFA4,NDUFA6,SDHA,NDUFB2,PRKAG2,NDUFV1,MAP3K5 |
| AMPK signaling pathway | PPP2R5D,PFKL,INS,FBP2,PPP2R2C,G6PC3,CPT1B,ULK1,RPS6KB2,AKT3 |
| Adipocytokine signaling pathway | G6PC,NFKBIAB,RELA,AGRP,CPT1B,G6PCA.1,PRKAG1,ADIPOQ,MAPK8B,SOCS3 |
Protein Function
ADIPOR1 has several biochemical functions, for example, adipokinetic hormone receptor activity,adiponectin binding,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADIPOR1 itself. We selected most functions ADIPOR1 had, and list some proteins which have the same functions with ADIPOR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| adiponectin binding | CDH13,ADIPOR2 |
| metal ion binding | GALNT12,ZBTB44,ATP1A1A.1,ALKBH7,CLEC7A,CYP2F2,ZYMND12,ZFP521,CYP2K16,GLI2A |
| identical protein binding | MAP1S,MID1,LYZ1,SH3GL1,APLP1,SLC22A1,CUBN,PRMT1,JMJD6,ZDHHC17 |
| adipokinetic hormone receptor activity | ADIPOR2 |
| protein kinase binding | AKAP1,RFFL,USF1,SNAP91,FBXO7,LIPE,PLK1,CD36,NEK9,ILK |
| protein heterodimerization activity | TYR,HIST1H2BF,ADRA2A,POLE3,RELA,HIST1H2AB,ADD2,MPP7,H3F3B.1,BMP6 |
| receptor activity | CD1D,SLC1A5,PLAUR,ABP1,FOLR1,NEO1,TREM2,ERBB3B,KIR2DL1,DERL1 |
Interacting Protein
ADIPOR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADIPOR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADIPOR1.
APPL1;NAA20;STK11;ynbB;DPH3;NFKBIL1;MYC
Resources
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References
- Su, YC; Xiang, RL; et al. Decreased submandibular adiponectin is involved in the progression of autoimmune sialoadenitis in non-obese diabetic mice. ORAL DISEASES 20:744-755(2014).
- Li, JH; Su, SY; et al. Analysis of the association between adiponectin, adiponectin receptor 1 and diabetic cardiomyopathy. EXPERIMENTAL AND THERAPEUTIC MEDICINE 7:1023-1027(2014).
