ADCYAP1
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Official Full Name
adenylate cyclase activating polypeptide 1 (pituitary) -
Overview
Pituitary adenylate cyclase-activating polypeptide also known as PACAP is a protein that in humans is encoded by the ADCYAP1 gene. PACAP is similar to vasoactive intestinal peptide. One of its effects is to stimulate enterochromaffin-like cells. It binds to vasoactive intestinal peptide receptor. -
Synonyms
ADCYAP1;PACAP;adenylate cyclase activating polypeptide 1 (pituitary);pituitary adenylate cyclase-activating polypeptide;MGC126852;OTTHUMP00000162201;PACAP 38;PRP-48;Pituitary adenylate cyclase-activating polypeptide 27;PACAP-27;PACAP27;Pituitary adenylate cyclase-activating polypeptide 38;PACAP-38;PACAP38
Recombinant Proteins
- Chicken
- Mouse
- Human
- Rat
- Mammalian Cells
- E.coli
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- T7
- GST
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
ADCYAP1 involved in several pathways and played different roles in them. We selected most pathways ADCYAP1 participated on our site, such as Activation of TRKA receptors,Class B/2 (Secretin family receptors),G alpha (s) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADCYAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Class B/2 (Secretin family receptors) | EMR3,EMR2,CD97,PTHRP2,GNB3B,CRHB,PTH2,GNB3A,PTH,ADCYAP1B |
| GPCR downstream signaling | NMU,ADORA2A,OPN4.1,GCGA,GPR68,ARHGEF3,CNR2,RGS7,PNOCB,PROKR2 |
| NGF signalling via TRKA from the plasma membrane | RIT2,NTF7,KIDINS220B,DNAL4B,RIT1,DNAL4A,DNAL4 |
| G alpha (s) signalling events | PDE10A,ADORA2A,ADCYAP1B,CRHR2,GCGA,INSL3,CALCB,PTH2,PTHRP2,ADM2A |
| GPCR ligand binding | GHRH,RCA2.1,PENKB,NMBB,NMS,PMCH,TAS2R3,INSL3,CCR8,AGTR2 |
| Activation of TRKA receptors | ADORA2A,ADCYAP1R1,NTF7 |
| Insulin secretion | ATF4,ITPR3,CAMK2D,VAMP2,KCNN2,ATP1A4,ATP1B2,KCNMB2,PRKCB,CREB5 |
Protein Function
ADCYAP1 has several biochemical functions, for example, neuropeptide hormone activity,peptide hormone receptor binding,pituitary adenylate cyclase activating polypeptide activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADCYAP1 itself. We selected most functions ADCYAP1 had, and list some proteins which have the same functions with ADCYAP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptide hormone receptor binding | FYN,RUNDC3A,NPPC,PTPN11,LEP,PTHLH,JAK2,PTH,NPPA,PTHLHA |
| protein binding | RPS20,ACACB,CXCR5,MRPL13,FAM53C,HIST1H2BE,IFI35,SH3RF1,NEURL1B,MSH6 |
| receptor signaling protein activity | RAF1B,RGS14A,BAG4,IL1RL1,ARF1,TIAM2,KLK1B3,FLRT2,KLK1B4,FLRT1 |
| neuropeptide hormone activity | NPPA,PENK,C12orf39,AVP,CALCB,PYYA,AGRP,GAL,TRH,GRP |
| receptor binding | FRK,TNFSF13,CD2,ADIPOQ,CX3CL1,FGF6B,HMGCL,AMH,TNFSF15,NXPH3 |
Interacting Protein
ADCYAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADCYAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADCYAP1.
CLU;DPP4;FAP
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