ADAR
-
Official Full Name
adenosine deaminase, RNA-specific -
Overview
This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. -
Synonyms
ADAR;adenosine deaminase, RNA-specific;G1P1, IFI4, interferon induced protein 4;double-stranded RNA-specific adenosine deaminase;ADAR1;dsRNA adenosine deaminase;interferon-induced protein 4;interferon-inducible protein 4;adenosine deaminase actin
Recombinant Proteins
- Rat
- Human
- Zebrafish
- Mouse
- Mammalian Cell
- HEK293
- Wheat Germ
- Human cells
- E.coli
- HEK293T
- E. coli
- Mamanlian cells
- His
- Myc&DDK
- GST
- Non
- Flag
- His&Fc&Avi
- His&SUMO
- Fc
Involved Pathway
ADAR involved in several pathways and played different roles in them. We selected most pathways ADAR participated on our site, such as C6 deamination of adenosine,Cytokine Signaling in Immune system,Cytosolic DNA-sensing pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine Signaling in Immune system | NRG2A,NRG3,SPRED1,PEBP1,USP18,TRIM38,IFIT12,PELI3,HLA-DQB2,EIF4E3 |
| Gene Expression | PTBP1B,ZNF606,ZNF710,ZFP90,PAIP1,DDX6,POU2F1,ZNF100,THG1L,ZFP2 |
| Cytosolic DNA-sensing pathway | IRF3,POLR1D,IFNA6,IFNA3,IFNPHI3,IRF7,CXCL10,RELA,IFN-a,Ifna15 |
| Immune System | ACTR2B,CSHL1,ACTR1A,MGC174152,SPSB2,SIGLEC12,CTSB,EIF4G2,CTSH,RNF25 |
| Formation of editosomes by ADAR proteins | ADARB1A,ADARB1 |
| C6 deamination of adenosine | ADARB1A,ADARB1 |
| Influenza A | NFKBIA,Ifna15,EIF2AK1,STAT1,IRAK4,AKT1,PIK3R1,IFN-a,AKT2,HSPA8 |
| Interferon Signaling | EIF4G2,IFIT14,XAF1,EIF4E3,TRIM5,IFIT8,TRIM26,TRIM68,IFIT2,IFIT3 |
Protein Function
ADAR has several biochemical functions, for example, DNA binding,double-stranded RNA adenosine deaminase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAR itself. We selected most functions ADAR had, and list some proteins which have the same functions with ADAR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| double-stranded RNA adenosine deaminase activity | ADARB1,ZBP1,PKZ |
| protein binding | KIAA0408,LDOC1,CNOT1,ERAP1,ZNF649,SEPT11,NPM3,C8orf33,CDR2,VPS8 |
| DNA binding | MEF2AA,ZNF69,ZSCAN18,ZNF445,MIXL1,APEX2,RARGA,ZNF684,ERCC6L2,OTX1B |
| metal ion binding | KLF15,ZFP667,RBM4.1,ZFP518A,ZBTB26,FREM2,ALPPL2,FOXP1,XPA,OGDH |
| poly(A) RNA binding | RBM19,UPF1,NSUN2,ETF1A,CLK3,NMD3,GRN,UTP14A,TPT1,C1orf35 |
Interacting Protein
ADAR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAR here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAR.
q99ib8-pro_0000045599;TGM2;cysK;q81xj3_bacan;pre-let-7a;AIM2;XRCC3;NS;ZFC3H1;MYC;NS;Junb;HNRNPA1;e3_vaccw;MATR3;Fus;Sesn2
Resources
Related Services
Related Products
References
- Saldi, TK; Ash, PEA; et al. TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA. EMBO JOURNAL 33:2947-2966(2014).
- Rima, BK; Gatherer, D; et al. Stability of the Parainfluenza Virus 5 Genome Revealed by Deep Sequencing of Strains Isolated from Different Hosts and following Passage in Cell Culture. JOURNAL OF VIROLOGY 88:3826-3836(2014).
