ACTL6B
-
Official Full Name
actin-like 6B -
Overview
The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain. -
Synonyms
ACTL6B;actin-like 6B;actin like 6 , ACTL6;actin-like protein 6B;BAF53B;arpNalpha;hArpN alpha;actin-like 6;BRG1-associated factor 53B;actin-related protein Baf53b;53 kDa BRG1-associated factor B;ACTL6
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Zebrafish
- Rat
- Mammalian Cell
- Wheat Germ
- E.coli
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- C-His-Flag
Involved Pathway
ACTL6B involved in several pathways and played different roles in them. We selected most pathways ACTL6B participated on our site, such as Chromatin modifying enzymes,Chromatin organization,Prostate Cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTL6B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RMTs methylate histone arginines | SMARCC2,WDR77,SMARCB1A,SMARCD3,SMARCA2,PRMT6,SMARCC1B,PRMT7,COPRS,SMARCD3B |
| Prostate cancer | TCF7L2,MDM2,MAPK1,HSP90B1,NRAS,TRP53,PDGFA,BRAF,PDGFRB,Pdgfa&Pdgfb |
| Chromatin modifying enzymes | SUZ12,JHDM1D,MSL3,KDM4D,ARID4A,KIAA1267,ELP4,SAP30,VPS72,DNMT3A |
| Chromatin organization | EPC1,KDM3A,YEATS4,PAX3A,SMARCE1,PADI6,KDM1B,SETD3,USP22,SMARCC2 |
Protein Function
ACTL6B has several biochemical functions, for example, structural constituent of cytoskeleton,transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTL6B itself. We selected most functions ACTL6B had, and list some proteins which have the same functions with ACTL6B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription coactivator activity | CREBBP,NFYC,PSMD9,USP22,Ankar,PER2,PRDM16,RXRB,TADA1,SNW1 |
| structural constituent of cytoskeleton | TUBA7L,ARPC5,TUBB2A,VILL,TPM1,TUBA3D,TUBA8L2,SPTB,KRT17,DMD |
Interacting Protein
ACTL6B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTL6B here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTL6B.
SMARCA2;COQ9;TK1;ANXA7;CDKN1A;GSK3B;PLK1;CSNK2B;ATM;SMN1
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