ACTL6A
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Official Full Name
actin-like 6A -
Overview
This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq, Jul 2008] -
Synonyms
ACTL6A;actin-like 6A;Arp4;ACTL6;BAF53A;INO80K;ARPN-BETA;actin-like protein 6A;BAF53;arpNbeta;hArpN beta;INO80 complex subunit K;actin-related protein 4;BAF complex 53 kDa subunit;BRG1-associated factor 53A;actin-related protein Baf53a;53 kDa BRG1-associated factor A
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- T7
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
ACTL6A involved in several pathways and played different roles in them. We selected most pathways ACTL6A participated on our site, such as C-MYC pathway,Chromatin modifying enzymes,Chromatin organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTL6A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HATs acetylate histones | TADA2A,ZZZ3,MSL2,RBB4L,MORF4L2,JADE1,KAT7B,ING5B,TAF6L,ELP2 |
| Chromatin organization | DPY30,ACTL6B,KAT7A,MSL2B,KDM4B,KDM2B,PHF17,RBBP5,KIAA1267,KDM2AA |
| Gastric cancer network 1 | TPX2,ECT2,S100P,SMOC2,MYBL2,ESM1,RNF216,LIN9,TOP2A,GATS |
| C-MYC pathway | KAT5,RUVBL2,MYC,HBP1 |
| DNA Repair | RNF111,PARP1,RAD51AP1,DDB1,CHD1L,PPIE,THRSP,RAD9B,YY1,CHEK2 |
| DNA Damage Recognition in GG-NER | MCRS1,TFPT,PARP1,INO80B,YY1,CETN2,INO80C,INO80,INO80E,PARP2 |
| Global Genome Nucleotide Excision Repair (GG-NER) | YY1,USP45,CHD1L,MCRS1,INO80E,INO80,COPS7A,TFPT,INO80C,COPS2 |
| Chromatin modifying enzymes | KDM4A,SMARCD3,RBBP7,MEAF6,SAP30,PRMT5,KDM2AA,SUDS3,SUZ12,PHF15 |
Protein Function
ACTL6A has several biochemical functions, for example, contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding,contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTL6A itself. We selected most functions ACTL6A had, and list some proteins which have the same functions with ACTL6A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding | HDAC2,MBD3,CHD4,SMARCE1,SMARCB1,SMARCC2,SMARCA4,MTA2,GATAD2B,SMARCC1 |
| contributes_to nucleosomal DNA binding | SMARCE1,MTA2,SMARCB1,HDAC2,ACTB,HDAC1,RBBP4,GATAD2B,MBD3,SMARCA4 |
| chromatin binding | MEIS3,TLE4,BAZ1B,EBF2,TCF7L2,NR5A1A,ADNP,KDM6B,HMGB3B,ATF2 |
| protein binding | BEX1,UTF1,FBF1,DUSP26,TRIM22,C22orf29,ZCCHC8,NR2C1,RPP38,TET3 |
| contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding | MTA2,RBBP4,SMARCE1,SMARCC1,CHD4,SMARCA4,HDAC1,SMARCB1,ACTB,GATAD2B |
| transcription coactivator activity | TAF6L,JUNB,PRMT2,PER2,RXRB,CBFB,TFAP2B,PQBP1,SUPT3H,RIPK3 |
Interacting Protein
ACTL6A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTL6A here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTL6A.
MRGBP;RUVBL2;RUVBL1
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