ACAN
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Official Full Name
aggrecan -
Overview
This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008] -
Synonyms
ACAN;aggrecan;AGC1;SEDK;AGCAN;CSPG1;MSK16;CSPGCP;aggrecan core protein;large aggregating proteoglycan;cartilage-specific proteoglycan core protein;chondroitin sulfate proteoglycan core protein 1
Recombinant Proteins
- Human
- Mouse
- Cattle
- Rat
- Chicken
- Mammalian cells
- C-His
- Mammalian Cell
- Wheat Germ
- E.coli
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- Non
- His
- GST
- His&T7
- His&S
- His&Fc&Avi
Involved Pathway
ACAN involved in several pathways and played different roles in them. We selected most pathways ACAN participated on our site, such as Defective B4GALT1 causes B4GALT1-CDG (CDG-2d),Defective CHST6 causes MCDC1,Defective ST3GAL3 causes MCT12 and EIEE15, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACAN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Diseases of glycosylation | FMOD,OGN,KERA,PRELP |
| ECM proteoglycans | MUSK,HAPLN1,DAG1,MATN3B,COL9A3,BGNA,VCANB,COL9A1,MATN4,MATN3 |
| Disease | CCR5,DERL2,ARF1,ANTXR1,TNKS,TAF1L,CCDC59,PDCD6IP,AP2A1,FGFR1OP |
| Defective CHST6 causes MCDC1 | FMOD,PRELP,KERA,OGN |
| Degradation of the extracellular matrix | MMP19,BMP1B,MGC174152,ELANE,ADAMTS4,MMP10,COL25A1,COL19A1,ADAM15,NID1 |
| Diseases associated with glycosaminoglycan metabolism | FMOD,OGN,KERA,PRELP |
| Defective ST3GAL3 causes MCT12 and EIEE15 | PRELP,FMOD,KERA,OGN |
| Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) | PRELP,FMOD,KERA,OGN |
Protein Function
ACAN has several biochemical functions, for example, carbohydrate binding,extracellular matrix structural constituent,hyaluronic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACAN itself. We selected most functions ACAN had, and list some proteins which have the same functions with ACAN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| extracellular matrix structural constituent | COL2A1A,COL1A1B,COL4A3,COL5A3B,KAL1,FBN2B,BGN,PRELP,MATN1,ELN |
| metal ion binding | RUFY4,ZFYVE16,FHL1A,CYP46A1.2,ZNF133,KLF6,ZBTB4,NEURL3,NEK1,RNF34A |
| hyaluronic acid binding | TNFAIP6,NCAN,C1QBP,BCAN,VCANB,HAPLN1A,CD44,HAPLN1,STAB2,KIAA1199 |
| carbohydrate binding | NOMO1,REG1B,NCAN,CD207,GALNT12,CD209A,CD302,LGALS13,GALNT14,LGALS9L1 |
| protein binding | USP49,C18orf1,ACACA,CIR1,RPH3A,DNM1,HIST1H4H,DOK6,DNAJB4,KNDC1 |
Interacting Protein
ACAN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACAN here. Most of them are supplied by our site. Hope this information will be useful for your research of ACAN.
PCOLCE
Resources
Research Area
Chondrogenesis MarkersOsteoclast Markers
Osteoblast and Osteoclast Markers
Hyaluronan (HA) binding Proteins
Proteoglycans
Related Services
Related Products
References
- Li, J; Xie, ZG; et al. Calcitonin treatment is associated with less severe osteoarthritis and reduced toll-like receptor levels in a rat model. JOURNAL OF ORTHOPAEDIC SCIENCE 19:1019-1027(2014).
- Zanotti, S; Canalis, E; et al. Interleukin 6 mediates selected effects of Notch in chondrocytes. OSTEOARTHRITIS AND CARTILAGE 21:1766-1773(2013).
