ACAD8
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Official Full Name
acyl-CoA dehydrogenase family, member 8 -
Overview
This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. The encoded protein is a mitochondrial enzyme that functions in catabolism of the branched-chain amino acid valine. Defects in this gene are the cause of isobutyryl-CoA dehydrogenase deficiency. -
Synonyms
ACAD8;acyl-CoA dehydrogenase family, member 8;acyl Coenzyme A dehydrogenase family, member 8;isobutyryl-CoA dehydrogenase, mitochondrial;ACAD 8;Activator-recruited cofactor 42 kDa component;Acyl CoA dehydrogenase family member 8;Acyl Coenzyme A dehydrogenase family member 8;ARC42;FLJ22590;IBD;acyl-Coenzyme A dehydrogenase family, member 8;ACAD-8
Recombinant Proteins
- Zebrafish
- Mouse
- Human
- Chicken
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- GST
- T7
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ACAD8-11374Z | Recombinant Zebrafish ACAD8 | Mammalian Cell | Zebrafish | His |
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| ACAD8-1160M | Recombinant Mouse ACAD8 Protein | Mammalian Cell | Mouse | His |
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| ACAD8-129H | Recombinant Human ACAD8 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| ACAD8-130H | Recombinant Human ACAD8 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| ACAD8-211H | Recombinant Human ACAD8 protein, T7-tagged | E.coli | Human | T7 | 23-415 a.a. |
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| ACAD8-26H | Recombinant Human ACAD8, T7-tagged | E.coli | Human | T7 | 1-415 a.a. |
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| ACAD8-338H | Recombinant Human acyl-CoA dehydrogenase family, member 8, His-tagged | E.coli | Human | His | 23-415 a.a. |
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| ACAD8-5336C | Recombinant Chicken ACAD8 | Mammalian Cell | Chicken | His |
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| ACAD8-9116HCL | Recombinant Human ACAD8 293 Cell Lysate | HEK293 | Human | Non |
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| Acad8-1485M | Recombinant Mouse Acad8 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| ACAD8-235M | Recombinant Mouse ACAD8 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| ACAD8-235M-B | Recombinant Mouse ACAD8 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| ACAD8-893HF | Recombinant Full Length Human ACAD8 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 415 amino acids |
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Involved Pathway
ACAD8 involved in several pathways and played different roles in them. We selected most pathways ACAD8 participated on our site, such as Valine, leucine and isoleucine degradation,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACAD8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | PIGV,PIP5KL1,NDUFV3,LDHBA,ETNK2,DHRS4,CELL,FUT6,ALDH18A1,POLR1E |
| Valine, leucine and isoleucine degradation | ACAA1,AOX4,HMGCS2,MCCC2,ALDH3A2A,ALDH2,HMGCLL1,AUH,IL4I1,ALDH9A1A.1 |
Protein Function
ACAD8 has several biochemical functions, for example, acyl-CoA dehydrogenase activity,electron carrier activity,fatty-acyl-CoA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACAD8 itself. We selected most functions ACAD8 had, and list some proteins which have the same functions with ACAD8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| electron carrier activity | FDX1B,TXNRD3,COX7A1,CYBA,UGDH,COX11,SH3BGRL3,ACAD11,GLRX2,ADH5 |
| fatty-acyl-CoA binding | ACBD5,DBIL5,ACADS,ACBD5A,SOAT1,ACOT7,ACBD6,ACBD4,ACOX2,ECI2 |
| oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor | GCDHB,ACAD11,ACOX1,ACOXL,ACOX2,ACADM,GCDHA,GCDH,ACAD9,ETFA |
| acyl-CoA dehydrogenase activity | ACADSB,ACOX2,ACADVL,ETFA,GCDHA,ACADS,ACOX3,GCDHB,ACADL,ACOXL |
| flavin adenine dinucleotide binding | GSR,KMO,AIFM3,NOS3,AIFM4,TXNRD3,KDM1A,ACOX3,GCDH,ACADL |
Interacting Protein
ACAD8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACAD8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACAD8.
Nek2;ETS1;TSG101;IPO8;CKAP5;Tgfbr1;LDHD;DLG3
Resources
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References
- Buckel, W; Zhang, J; et al. Enzyme catalyzed radical dehydrations of hydroxy acids. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1824:1278-1290(2012).
- Sadri, H; Mielenz, M; et al. Plasma leptin and mRNA expression of lipogenesis and lipolysis-related factors in bovine adipose tissue around parturition. JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION 95:790-797(2011).
