YWHAH
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Official Full Name
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Eta Polypeptide -
Overview
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. -
Synonyms
YWHAH;tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide;YWHA1;14-3-3 eta;Protein AS1;14-3-3 protein eta;OTTHUMP00000028905
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- Insect Cell
- HEK293
- E. coli
- HEK293T
- Mammalian cells
- Non
- His
- GST
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
YWHAH involved in several pathways and played different roles in them. We selected most pathways YWHAH participated on our site, such as Cell cycle,Oocyte meiosis,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with YWHAH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oocyte meiosis | PGR,CALM,ADCY1A,PPP2R5D,CPEB4,PPP1CA,RPS6KAL,PPP3R1B,CDC27,INSB |
| Cell cycle | SYCE1,USO1,MCM3L,ANAPC7,FOXM1,TOP2A,RBX1,HJURP,DYRK1A,DMC1 |
| Viral carcinogenesis | NFKB2,HPN,RANBP1,MRPS18B,HNRNPK,HIST1H2BG,GTF2A1L,HLA-E,TRAF2,HIST1H2BB |
| Hippo signaling pathway | PARD3,CTNNA3,BMP2,YWHAZ,FBXW11,CCND2,BMP6,TGFBR1,ACTG1,ITGB2 |
| PIK-Akt signaling pathway | IFNAR1,PHLPP1,GNG11,IL3RA,FASLG,TSC1,FGF9,LPAR4,IL2RB,ITGA10 |
| Epstein-Barr virus infection | IRF3,AKAP8L,MAPK13,TRADD,ICAM1,PIK3R5,POLR2E,PSMC2,HLA-DQA1,HLA-DPA1 |
Protein Function
YWHAH has several biochemical functions, for example, actin binding,enzyme binding,glucocorticoid receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by YWHAH itself. We selected most functions YWHAH had, and list some proteins which have the same functions with YWHAH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sodium channel regulator activity | GPD1L,PTPN3,RANGRF,SCN1BB,NEDD4L,SCN3B,SGK2A,FGF13,NOS1,SGK2B |
| protein heterodimerization activity | PIK3R1,HIST4H4,TWIST1,MEF2C,H2-AA,PDGFA,HIST1H3F,H3F3C,P4HB,ANO2 |
| actin binding | MYO3B,MYLK,WASLB,CNN3B,SPNA1,HOMER2,COBL,SPTAN1,FSCN1,CAPG |
| insulin-like growth factor receptor binding | IGF2B,GNAS,SOCS2,SOCS1,IGF2,IGF1,IGF3,IGF2A,INSR,IRS1 |
| glucocorticoid receptor binding | STAT5B,STAT3,ETS2,GRIP1,FKBP4,EP300,NR4A2,CEBPB,NRIP1 |
| ion channel binding | HSP90AB1,YWHAQ,SRC,RNF207,GPD1L,YWHAE,PRNP,PPP1R9B,FKBP1A,CALM1 |
| protein domain specific binding | PPP3R1,RXRA,TRP63,HOMER3,CEP68,NLRP1,MLF1,COX4I2,VPS4A,SFN |
| enzyme binding | N4BP2L2,TSPAN14,CDK19,GBP1,GOT2,BCHE,TSPAN33,DAXX,MLEC,HIST1H2AD |
| protein binding | COBRA1,VPS36,NKRF,ABCB9,FXYD7,TMCO6,HDAC5,DSC2,CTSL2,TMSB4X |
Interacting Protein
YWHAH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with YWHAH here. Most of them are supplied by our site. Hope this information will be useful for your research of YWHAH.
MARK2;RAF1;HDAC4;CDC25B
Resources
Research Area
Apoptosis Adaptor ProteinsAdaptor Proteins
phospho-Serine/phospho-Threonine Binding Proteins
Adaptor Proteins in the Akt Pathway
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References
