WNT6

  • Official Full Name

    wingless-type MMTV integration site family, member 6

  • Overview

    The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level. [provided by RefSeq, Jul 2008]

  • Synonyms

    WNT6;wingless-type MMTV integration site family, member 6;protein Wnt-6

Recombinant Proteins

  • Chicken
  • Mouse
  • Human
  • Mammalian Cell
  • HEK293
  • E.coli
  • Wheat Germ
  • In Vitro Cell Free System
  • E. coli
  • His
  • Non
  • His&Fc&Avi
  • GST
  • His&GST
  • His&ABP
Cat.# Product name Source (Host) Species Tag Protein Length Price
WNT6-1746C Recombinant Chicken WNT6 Mammalian Cell Chicken His
WNT6-18575M Recombinant Mouse WNT6 Protein Mammalian Cell Mouse His
WNT6-290HCL Recombinant Human WNT6 293 Cell Lysate HEK293 Human Non
WNT6-10200M Recombinant Mouse WNT6 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
WNT6-10200M-B Recombinant Mouse WNT6 Protein Pre-coupled Magnetic Beads HEK293 Mouse
WNT6-120H Recombinant Human WNT6 Protein E.coli Human
WNT6-12H Recombinant Human WNT6 Protein, GST-tagged Wheat Germ Human GST
WNT6-6263HF Recombinant Full Length Human WNT6 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 365 amino acids
WNT6-6HFL Recombinant Full Length Human WNT6 Protein, His&GST-tagged E. coli Human His&GST Full L.
WNT6-7H Recombinant Human WNT6 Protein, His&ABP-tagged E. coli Human His&ABP Pro32-Phe82aa

    Involved Pathway

    WNT6 involved in several pathways and played different roles in them. We selected most pathways WNT6 participated on our site, such as Wnt signaling pathway,Hedgehog signaling pathway,Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with WNT6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pathways in cancer FAS,HSP90AB1,WNT2,RASSF5,Fgf15,GNG2,EGLN2,HHIP,GNG5,TGFBR2
    Melanogenesis WNT8A,CALM3B,PRKACBA,CREB3L2,WNT4A,MAPK3,EDNRB2,KITLGB,TYRP1,FZD5
    Hedgehog signaling pathway DYRK1A,CSNK1G2B,GAS1A,WNT5B,GSK3B,RAB23,SKIA,WNT11R,WNT11B,WNT2BB
    Proteoglycans in cancer ITGA2,ERBB2,PLCG2,RDX,MAP2K1,ROCK1,PLAUR,FZD5,PPP1CA,FLNA
    Wnt signaling pathway CAMK2D,PLCB1,CACYBP,WNT4A,PRICKLE2B,DAAM2,PORCNL,PRKACAA,TBL1X,TCF7L2
    Signaling pathways regulating pluripotency of stem cells HAND1,ESX1,TCF3,JARID2,KRAS,HESX1,POU5F1,IGF1,PIK3CB,HOXB1
    HTLV-I infection TBPL1,PIK3R1,MYB,DVL1,TNFRSF13C,HLA-A,MAP3K3,APC2,ATF4,SLC25A31
    Basal cell carcinoma AXIN2,FZD8,WNT1,WNT3,TCF7,APC,SETD6,PTCH1,WNT4,TP53
    Hippo signaling pathway TEAD1,WNT8B,FZD8,FZD6,PPP1CA,BTRC,FZD10,TGFB2,LATS1,NKD1

    Protein Function

    WNT6 has several biochemical functions, for example, frizzled binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WNT6 itself. We selected most functions WNT6 had, and list some proteins which have the same functions with WNT6. You can find most of the proteins on our site.

    Function Related Protein
    frizzled binding DVL3,WNT4B,RSPO3,WNT1,FZD7,NDP,WNT11,DVL2,WNT11R,WNT3A

    Interacting Protein

    WNT6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WNT6 here. Most of them are supplied by our site. Hope this information will be useful for your research of WNT6.

    WNT6 Related Signal Pathway

    Resources

    Gene Families

    What Is Wingless-INT (WNT)

    Research Area

    Wnt Ligands (Wnts)

    References

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