WNT3
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Official Full Name
wingless-related MMTV integration site 3 -
Overview
Defects in WNT3 are the cause of autosomal recessive tetra-amelia (ARTTRA). Tetra-amelia is a rare human genetic disorder characterized by complete absence of all four limbs and other anomalies such as craniofacial, nervous system, pulmonary, skeletal and urogenital defects. -
Synonyms
WNT3;wingless-related MMTV integration site 3;Int-4;Wnt-3;proto-oncogene Wnt-3;proto-oncogene Int-4;proto-oncogene protein Wnt-3
Recombinant Proteins
- Mouse
- Human
- Chicken
- Zebrafish
- Cattle
- E.coli
- Human Cell
- Mammalian Cell
- Wheat Germ
- HEK293
- CHO
- Yeast
- In Vitro Cell Free System
- Non
- His
- StrepII
- GST
- Flag
- His&SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| WNT3-5160M |
Active Recombinant Mouse WNT3
|
Mouse | Non |
|
||
| WNT3-3738H | Recombinant Human WNT3, His-tagged | E.coli | Human | His | 1-355aa |
|
| WNT3-3076H | Recombinant Human WNT3 protein, His-tagged | E.coli | Human | His | 130-306 aa |
|
| WNT3-205H | Recombinant Human WNT3, StrepII-tagged | Human Cell | Human | StrepII | 22-355, 334 a.a. |
|
| WNT3-3658C | Recombinant Chicken WNT3 | Mammalian Cell | Chicken | His |
|
|
| WNT3-5161H | Recombinant Human WNT3, GST-tagged | Wheat Germ | Human | GST |
|
|
| WNT3-6430Z | Recombinant Zebrafish WNT3 | Mammalian Cell | Zebrafish | His |
|
|
| WNT3-296HCL | Recombinant Human WNT3 293 Cell Lysate | HEK293 | Human | Non |
|
|
| WNT3-3739H | Recombinant Human WNT3 Protein, DDK-tagged | CHO | Human | Flag |
|
|
| WNT3-5162M | Recombinant Mouse WNT3 Protein, His-tagged | E.coli | Mouse | His | 22-355aa |
|
| WNT3-5163M | Recombinant Mouse WNT3 Protein, His-SUMO-tagged | E.coli | Mouse | His&SUMO | 22-355aa |
|
| WNT3-5164M | Recombinant Mouse WNT3 Protein, His-tagged | Yeast | Mouse | His | 22–355aa |
|
| WNT3-549HF | Recombinant Full Length Human WNT3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 385 amino acids |
|
| WNT3-584C | Recombinant Cattle WNT3 Protein, His-tagged | E.coli | Cattle | His | Val19-Lys355 |
|
Involved Pathway
WNT3 involved in several pathways and played different roles in them. We selected most pathways WNT3 participated on our site, such as Wnt signaling pathway,Hedgehog signaling pathway,Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with WNT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling pathways regulating pluripotency of stem cells | AXIN1,WNT16,ESX1,PIK3R5,WNT1,FZD8,PCGF1,MAP2K1,FZD9,WNT3A |
| Pathways in cancer | PRKCA,EGLN2,GLI3,GNG12,FGF7,ROCK1,DAPK3,PDGFA,BIRC5,VEGFB |
| Melanogenesis | CALM3B,EP300,HRAS,a,FZD2,GNAO1,WNT4,WNT11B,WNT8B,DVL3A |
| Basal cell carcinoma | WNT7A,WNT5B,WNT8B,SUFU,FZD3,DVL3,APC2,TCF7,GLI1,FZD6 |
| Proteoglycans in cancer | HPSE2,FZD1,PXN,MDM2,IL12B,CAMK2G,NANOG,PTK2,WNT5A,ROCK1 |
| Hippo signaling pathway | CTGF,CDH1,WNT4,FZD6,MOBKL1A,PPP1CA,TGFB2,LEF1,PARD6B,AXIN2 |
| Wnt signaling pathway | CCND1,DKK1,DVL3A,FZD9,FRAT2,FBXW2,FOSL1,RHOAA,SFRP2,WNT9B |
| HTLV-I infection | TGFB3,TERT,ANAPC4,FZD7,GSK3B,VAC14,LTBR,PIK3CG,TGFBR2,SPI1 |
| MicroRNAs in cancer | NOTCH4,SOCS1,MDM2,MMP16,HDAC4,Abcb1b,HRAS,TIMP3,MMP9,FSCN1 |
Protein Function
WNT3 has several biochemical functions, for example, frizzled binding,protein binding,protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WNT3 itself. We selected most functions WNT3 had, and list some proteins which have the same functions with WNT3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | DPM1,MTTP,UBAP1,TMEM14C,ACAD9,TRIM16,SUFU,CDKN1B,GCET2,POC1A |
| frizzled binding | WNT4,DVL1B,WNT2BA,DVL1,WNT9A,WNT6,FZD7,WNT2BB,FZD1,DVL2 |
| receptor agonist activity | GAS6,WNT2,WNT4,WNT8A,WNT7A,WNT1,WNT3A,WNT10B,WNT5A,SFRP2 |
| protein domain specific binding | RAPGEF3,PHRF1,SCAF1,HIST1H4D,COX4I2,TNFAIP1,Ar,MYH9,LIN7B,YWHAE1 |
Interacting Protein
WNT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WNT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of WNT3.
FZD7
WNT3 Related Signal Pathway
Resources
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Related Products
References
- Lighthouse, JK; Zhang, L; et al. MESD Is Essential for Apical Localization of Megalin/LRP2 in the Visceral Endoderm. DEVELOPMENTAL DYNAMICS 240:577-588(2011).
- Ettenberg, SA; Charlat, O; et al. Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107:15473-15478(2010).
