WISP1
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Official Full Name
WNT1 inducible signaling pathway protein 1 -
Overview
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011] -
Synonyms
WISP1;WNT1 inducible signaling pathway protein 1;CCN4;WISP1c;WISP1i;WISP1tc;WNT1-inducible-signaling pathway protein 1;CTC-458A3.8;CCN family member 4;WNT1 induced secreted protein 1;Wnt-1 inducible signaling pathway protein 1
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- Cynomolgus
- HEK293
- E.coli
- Mammalian Cells
- Human Cells
- C-His
- His
- Non
- His&Fc&Avi
Involved Pathway
WISP1 involved in several pathways and played different roles in them. We selected most pathways WISP1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with WISP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
WISP1 has several biochemical functions, for example, heparin binding,insulin-like growth factor binding,integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WISP1 itself. We selected most functions WISP1 had, and list some proteins which have the same functions with WISP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| integrin binding | DST,EGFL6,FBN1,Npnt,ADAM17,TGFBI,ICAM5,ANGPTL3,PPAP2B,CTGF |
| heparin binding | FGF14,CRISPLD2,VEGFB,CTGFB,NRP2,PF4,VTN,APPA,FGF9,HRG |
| insulin-like growth factor binding | CYR61L1,WISP1A,DEFB126,IGFBP6B,WISP1B,IGFBP5B,CTGFB,KAZALD3,IGF1RA,KAZALD2 |
Interacting Protein
WISP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WISP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WISP1.
UGGT1
Resources
Research Area
EMT InductionExtracellular Matrix Molecules
IGF Binding Protein & Regulator
p53 Pathway
Related Services
Related Products
References
- Klinke, DJ; et al. Induction of Wnt-Inducible Signaling Protein-1 Correlates with Invasive Breast Cancer Oncogenesis and Reduced Type 1 Cell-Mediated Cytotoxic Immunity: A Retrospective Study. PLOS COMPUTATIONAL BIOLOGY 10:-(2014).
- Yang, MJ; Zhao, X; et al. A role for WNT1-inducible signaling protein-1 in airway remodeling in a rat asthma model. INTERNATIONAL IMMUNOPHARMACOLOGY 17:350-357(2013).
