UNC5B
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Official Full Name
unc-5 homolog B (C. elegans) -
Overview
This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. -
Synonyms
UNC5B;unc-5 homolog B (C. elegans);unc5 (C.elegans homolog) b;netrin receptor UNC5B;p53RDL1;UNC5H2;6330415E02Rik;A630020F16;D10Bwg0792e;Netrin receptor UNC5B Precursor;p53 regulated receptor for death and life;p53 regulated receptor for death and life protein 1;p53-regulated receptor for death and life protein 1;Protein unc-5 homolog 2;Protein unc-5 homolog B;Protein XUNC 5;Transmembrane receptor Unc5H2;Unc 5 homolog 2;Unc 5 homolog B;UNC 5B;UNC5B_HUMAN;unc-5 homolog 2;OTTHUMP00000019771;OTTHUMP00000019772
Recombinant Proteins
- Rat
- Mouse
- Human
- Chicken
- Zebrafish
- Mammalian cells
- Human Cell
- Mammalian Cell
- CHO
- HEK293
- HEK293T
- Fc
- His
- Non
- His&Fc
- His&Fc&Avi
- Myc&DDK
Involved Pathway
UNC5B involved in several pathways and played different roles in them. We selected most pathways UNC5B participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with UNC5B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | DPYSL2,NRP1,IL17RD,KBTBD7,SPRED1,DPYSL5A,SPRED2,Plxna2,KIF4A,SRGAP1 |
Protein Function
UNC5B has several biochemical functions, for example, netrin receptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UNC5B itself. We selected most functions UNC5B had, and list some proteins which have the same functions with UNC5B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | DSTN,ZFC3H1,BAG1,RPGR,ZW10,CD226,PKHD1L1,ZWILCH,C2orf57,ITGB1BP2 |
| netrin receptor activity | UNC5C |
Interacting Protein
UNC5B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UNC5B here. Most of them are supplied by our site. Hope this information will be useful for your research of UNC5B.
Agap2;Ppp2r1b
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References
- Tu, T; Zhang, CX; et al. CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development. CELL RESEARCH 25:275-287(2015).
- Oksala, N; Parssinen, J; et al. Association of Neuroimmune Guidance Cue Netrin-1 and Its Chemorepulsive Receptor UNC5B With Atherosclerotic Plaque Expression Signatures and Stability in Human(s) Tampere Vascular Study (TVS). CIRCULATION-CARDIOVASCULAR GENETICS 6:579-587(2013).
