UMPS
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Official Full Name
uridine monophosphate synthetase -
Overview
This gene encodes a uridine 5-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. -
Synonyms
UMPS;uridine monophosphate synthetase;uridine 5-monophosphate synthase;orotate phosphoribosyl transferase and orotidine 5 decarboxylase;OMPdecase;OPRT;OPRtase;Orotate phosphoribosyltransferase phosphoribosyltransferase;Orotidine 5 phosphate decarboxylase;UMP synthase;Uridine 5 monophosphate synthase;OTTHUMP00000215261;orotate phosphoribosyltransferase;orotidine 5-phosphate decarboxylase
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rhesus macaque
- E.coli
- Mammalian Cell
- HEK293
- Insect Cell
- HEK293T
- Mammalian cells
- His
- His&T7
- Non
- His&Fc&Avi
- GST
- Myc&DDK
- Flag
Involved Pathway
UMPS involved in several pathways and played different roles in them. We selected most pathways UMPS participated on our site, such as Pyrimidine metabolism,Drug metabolism - other enzymes,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with UMPS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pyrimidine metabolism | POLR1A,CDA,POLR2A,POLR2GL,POLR3GL,POLD1,NME4,NME5,NME3,POLR2D |
| Drug metabolism - other enzymes | UGT1A7,UGT1A7C,UGT1A3,TPMT,UGT1A6A,ITPA,UGT1A4,UGT1A6B,UPP1,UPP2 |
| Metabolic pathways | UQCRFS1,ALDH7A1,COX6A2,HSD3B4,HSD17B10,CKB,ETNK1,NDUFA1,HPDA,LAP3 |
Protein Function
UMPS has several biochemical functions, for example, RNA binding,nucleic acid binding,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UMPS itself. We selected most functions UMPS had, and list some proteins which have the same functions with UMPS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleic acid binding | NABP2,FTSJD2,PUF60B,SALL3B,ZFP521,ZFP689,BICC1,RNASE9,ZNF367,REV3L |
| nucleotide binding | GNA13B,IGF1RB,MOCS2,RBM14,RAD51L1,PCXA,EIF4A1B,RAB25B,RBFOX1,MXE |
| zinc ion binding | SH3RF2,TGFB1I1,MGRN1,AGBL5,MANEA,TRIM109,SETDB1,ADAM7,OTUD7B,AEBP1 |
| RNA binding | HBP1,MBNL1,QKIA,RPL24,RNMTL1A,HNRPK,PES,ADAT1,RBM20,ADARB1 |
Interacting Protein
UMPS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UMPS here. Most of them are supplied by our site. Hope this information will be useful for your research of UMPS.
CASP4;USP50;CALU;A2M;NOS3;DLST;PIK3CA;PSEN1;RPS29;RAD51;CASP8;PAXIP1;ZNF227;RB1CC1;PLA2G12A;CDC42EP3;MYH6;Kif4;Nup98;Ccdc12
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References
- Ciuonzo, D; De Maio, A; et al. A Systematic Framework for Composite Hypothesis Testing of Independent Bernoulli Trials. IEEE SIGNAL PROCESSING LETTERS 22:1249-1253(2015).
- Tsao, N; Lee, MH; et al. The contribution of CMP kinase to the efficiency of DNA repair. CELL CYCLE 14:354-363(2015).
