UCP1
-
Official Full Name
uncoupling protein 1 (mitochondrial, proton carrier) -
Overview
Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. -
Synonyms
UCP1;uncoupling protein 1 (mitochondrial, proton carrier);UCP;mitochondrial brown fat uncoupling protein 1;SLC25A7;mitochondrial brown fat uncoupling protein;Solute carrier family 25 member 7;Thermogenin;UCP 1;UCP1_HUMAN;Uncoupling protein 1;OTTHUMP00000164611
Recombinant Proteins
- Rat
- Human
- Mouse
- Zebrafish
- Mesocricetus auratus
- Bovine
- Oryctolagus cuniculus (Rabbit)
- Ochotona dauurica (Daurian pika)
- Mus musculus
- Suncus murinus (Asian house shrew) (Musk shrew)
- Dicrostonyx groenlandicus (Northern collared lemming)
- Dog
- Phodopus sungorus (Striped hairy-footed hamster) (Djungarian hamster)
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli expression system
- Yeast
- His
- His&GST
- GST
- Flag
- His&Fc&Avi
- Non
- His&SUMO
Involved Pathway
UCP1 involved in several pathways and played different roles in them. We selected most pathways UCP1 participated on our site, such as PPAR signaling pathway,Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with UCP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PPAR signaling pathway | ANGPTL4,RXRGB,UBC,APOA2,HMGCS2,APOC3,FABP7B,FABP4,ACSL3,FABP7 |
| Huntingtons disease | Casp3,TFAM,HIP1,Atp5g2,TBPL1,ATP5F1,CREB3L2,NDUFA7,PLCB2,ATP5J |
Protein Function
UCP1 has several biochemical functions, for example, oxidative phosphorylation uncoupler activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UCP1 itself. We selected most functions UCP1 had, and list some proteins which have the same functions with UCP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| oxidative phosphorylation uncoupler activity | UCP3 |
Interacting Protein
UCP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UCP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UCP1.
Resources
Related Services
Related Products
References
- Brestoff, JR; Kim, BS; et al. Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. NATURE 519:242-+(2015).
- Maimaitiyiming, H; Norman, H; et al. CD47 Deficiency Protects Mice From Diet-induced Obesity and Improves Whole Body Glucose Tolerance and Insulin Sensitivity. SCIENTIFIC REPORTS 5:-(2015).
