UBE2T
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Official Full Name
ubiquitin-conjugating enzyme E2T (putative) -
Overview
The covalent conjugation of ubiquitin to proteins regulates diverse cellular pathways and proteins. Ubiquitin is;transferred to a target protein through a concerted action of a ubiquitin-activating enzyme (E1), a;ubiquitin-conjugating enzyme (E2), such as UBE2T, and a ubiquitin ligase (E3) (Machida et al., 2006 (PubMed;16916645)). -
Synonyms
UBE2T;ubiquitin-conjugating enzyme E2T (putative);ubiquitin-conjugating enzyme E2 T;HSPC150;ubiquitin-protein ligase T;ubiquitin carrier protein T;ubiquitin conjugating enzyme;cell proliferation-inducing gene 50 protein;HSPC150 protein similar to ubiquitin-conjugating enzyme;PIG50
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- Insect Cell
- Mammalian cells
- HEK293T
- GST
- Non
- His&SUMO
- His
- His&Strep
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
UBE2T involved in several pathways and played different roles in them. We selected most pathways UBE2T participated on our site, such as Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2T were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fanconi Anemia Pathway | RAD51,FANCA,DCLRE1A,POLK,PALB2,ATRIP,RPA1,PMS2,REV1,RPA2 |
Protein Function
UBE2T has several biochemical functions, for example, ATP binding,chromatin binding,ubiquitin conjugating enzyme activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2T itself. We selected most functions UBE2T had, and list some proteins which have the same functions with UBE2T. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin-protein transferase activity | PEX12,PDZRN3B,RNF10,RNF168,RNF41,ANKIB1A,UBE2R2,FBXW2,UBE2E3,TRIM28 |
| ubiquitin protein ligase binding | FZD5,FANCL,UBXN1,TXNIP,FOXO1,PER1,TRIB1,PIAS1,PRKACB,CKB |
| ubiquitin protein ligase activity | PDZD4,HACE1,ANAPC11,FBXW11,TRIM11,RNF149,RNF121,TMEM189,UBE2KB,MDM2 |
| chromatin binding | IFT74,HHEX,NSD1,TOP1,CENPA,MPO,SOX9A,TOX3,NCOA3,TGIF1 |
| ubiquitin conjugating enzyme activity | UBE2E1,CDC34,UBE2J1,UBE2H,UBE2J2,UBE2V1,UBE2S,UBE2C,UBE2QL1,UBE2V2 |
| ATP binding | EIF4A1,HELLS,SKIV2L2,LYN,PYGL,BMPR1AA,DDX25,STK35,ABCB4,PRKCQ |
Interacting Protein
UBE2T has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2T here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2T.
ARIH2;UBE2V1;MGRN1;TRIM27;PCGF2;RNF144B;LNX2;RNF128;MARCH5;AMFR;SNURF
Resources
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References
- Hodson, C; Purkiss, A; et al. Structure of the Human FANCL RING-Ube2T Complex Reveals Determinants of Cognate E3-E2 Selection. STRUCTURE 22:337-344(2014).
- Renaudin, X; Guervilly, JH; et al. Proteomic analysis reveals a FANCA-modulated neddylation pathway involved in CXCR5 membrane targeting and cell mobility. JOURNAL OF CELL SCIENCE 127:3546-3554(2014).
